Evidence map›Paper›PMID 33038668›Full record

ArticleNeuroImage. Clinical2020

Theta oscillations in prolactinomas: Neurocognitive deficits in executive controls.

Chenglong Cao, Wen Wen, Binbin Liu, Pan Ma, Sheng Li, Guozheng Xu, Jian Song

Open access · goldAbstract read
In one paragraph

Article in NeuroImage. Clinical, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Chenglong CaoThe First School of Clinical Medicine, Southern Medical University, Guangzhou 510515, China; Department of Neurosurgery, The General Hospital of Chinese PLA Central Theater Command, Wuhan 430070, China.
Wen WenSchool of Psychological and Cognitive Sciences, Peking University, Beijing 100871, China.
Binbin LiuWuhan University of Science and Technology, Wuhan 430000, China.
Pan MaWuhan Children's Hospital, Tongji Medical College of Huazhong University of Science & Technology, China.
Sheng LiSchool of Psychological and Cognitive Sciences, Peking University, Beijing 100871, China.
Guozheng XuThe First School of Clinical Medicine, Southern Medical University, Guangzhou 510515, China; Department of Neurosurgery, The General Hospital of Chinese PLA Central Theater Command, Wuhan 430070, China. Electronic address: docxgz@163.com.
Jian SongDepartment of Neurosurgery, The General Hospital of Chinese PLA Central Theater Command, Wuhan 430070, China. Electronic address: docsongjian@yahoo.com.
Peking University · CNWuhan General Hospital of Guangzhou · CNCentral Hospital of Wuhan · CNWuhan Children's Hospital · CNWuhan University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Impairment of cognitive functions has been reported in prolactinomas. However, the electrophysiological mechanisms of response activation and response inhibition in prolactinomas remain unclear. We recorded participants' scalp electroencephalography (EEG) in a visual Go/Nogo task. Compared to the healthy controls (HCs), the patients demonstrated worse performance and their prolactin (PRL) levels negatively correlated with behavioral results. Meanwhile, patients' P300 amplitudes in the Go and Nogo conditions were smaller than the HCs. The amplitudes of N200nogo in patients were smaller than the HCs as well. Lower frontal theta power was found in the patients than the HCs in both Go and Nogo conditions, which indicated a deficit in response activation and inhibition. Moreover, the PRL levels mediated the relationship between frontal theta power and behavior performance, implying that lower frontal theta power caused the dysfunction of response control by abnormally high PRL levels. Patients also showed lower occipital alpha power than the HCs, which suggested that the impaired response inhibition may arise from deficient attention control. Taken together, the present study revealed the neurocognitive discrepancies between prolactinomas and the HCs. The frontal theta oscillation was highlighted as the electrophysiological markers of the impaired response control in prolactinomas.

Indexed as

Pituitary NeoplasmsProlactinomaElectroencephalographyExecutive FunctionHumansInhibition, PsychologicalTheta RhythmN200P300ProlactinomasResponse activation and inhibitionTheta oscillation

Identifiers

PMID33038668
PMCPMC7554198
OpenAlexW3091116893

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.