ArticleDevelopmental cell2020
Comparative Super-Resolution Mapping of Basal Feet Reveals a Modular but Distinct Architecture in Primary and Motile Cilia.
Article in Developmental cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Successful oocyte transport through the oviduct does not depend on the longitudinal alignment of oviduct epithelial folds.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- DEUP1 functions as a scaffold for basal foot integrity and planar polarity in multiciliated cells.Nature communications · 2026Article
- Advances in high-resolution imaging of centrioles and cilia.Journal of cell science · 2025Review
- NME7 maintains primary cilium assembly, ciliary microtubule stability, and Hedgehog signaling.Life science alliance · 2025Article
- An amino acid-resolution interactome for motile cilia identifies the structure and function of ciliopathy protein complexes.Developmental cell · 2025Article
- A polarized multicomponent foundation upholds ciliary central microtubules.Journal of molecular cell biology · 2025Article
- Review
- Directional ciliary beats across epithelia require Ccdc57-mediated coupling between axonemal orientation and basal body polarity.Nature communications · 2024Article
- Distinct roles of Kif6 and Kif9 in mammalian ciliary trafficking and motility.The Journal of cell biology · 2024Article
- CEP112 coordinates translational regulation of essential fertility genes during spermiogenesis through phase separation in humans and mice.Nature communications · 2024Article
- Dual-color live imaging unveils stepwise organization of multiple basal body arrays by cytoskeletons.EMBO reports · 2024Article
- Formation and function of multiciliated cells.The Journal of cell biology · 2024Review
- Proteomic profiling of centrosomes across multiple mammalian cell and tissue types by an affinity capture method.Developmental cell · 2023Article
- Ciliogenesis membrane dynamics and organization.Seminars in cell & developmental biology · 2023Review
- Single-molecule imaging in the primary cilium.Methods in cell biology · 2023Article
- The apical ciliary adhesion complex is established at the basal foot of motile cilia and depends on the microtubule network.Scientific reports · 2022Article
- Cilia proteins are biomarkers of altered flow in the vasculature.JCI insight · 2022Article
- Visualizing the native cellular organization by coupling cryofixation with expansion microscopy (Cryo-ExM).Nature methods · 2022Article
- Nanometer-Scale Molecular Mapping by Super-resolution Fluorescence Microscopy.Methods in molecular biology (Clifton, N.J.) · 2022Article
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
Abstract
In situ molecular architecture analysis of organelles and protein assemblies is essential to understanding the role of individual components and their cellular function, and to engineering new molecular functionalities. Through a super-resolution-driven approach, here we characterize the organization of the ciliary basal foot, an appendage of basal bodies whose main role is to provide a point of anchoring to the microtubule cytoskeleton. Quantitative image analysis shows that the basal foot is organized into three main regions linked by elongated coiled-coil proteins, revealing a conserved modular architecture in primary and motile cilia, but showing distinct features reflecting its specialized functions. Using domain-specific BioID proximity labeling and super-resolution imaging, we identify CEP112 as a basal foot protein and other candidate components of this assembly, aiding future investigations on the role of basal foot across different cilia systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.