Evidence map›Paper›PMID 33038323›Full record

ArticleMolecular therapy : the journal of the American Society of Gene Therapy2021

Improved Noninvasive In Vivo Tracking of AAV-9 Gene Therapy Using the Perchlorate-Resistant Sodium Iodide Symporter from Minke Whale.

Susanna C Concilio, Lukkana Suksanpaisan, Linh Pham, Kah-Whye Peng, Stephen J Russell

Open access · hybridAbstract read
In one paragraph

Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Susanna C ConcilioDepartment of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA; Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN 55905, USA.
Lukkana SuksanpaisanImanis Life Sciences, LLC, Rochester, MN 55901, USA.
Linh PhamDepartment of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Kah-Whye PengDepartment of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA; Imanis Life Sciences, LLC, Rochester, MN 55901, USA.
Stephen J RussellDepartment of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA; Imanis Life Sciences, LLC, Rochester, MN 55901, USA. Electronic address: sjr@mayo.edu.
Mayo Clinic · USMayo Clinic in Arizona · US

Funding

Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI AKHILESH PANDEY · 1985 to 2026
$151.3M
Phase 2: NIS proteins with altered anion specificityR44TR001191 · NCATS · IMANIS LIFE SCIENCES, LLC · PI RUSSELL, STEPHEN J, SUKSANPAISAN, LUKKANA · 2017 to 2018
$1.5M
PhD Training Program in Virology and Gene TherapyT32AI132165 · NIAID · MAYO CLINIC ROCHESTER · PI ROBERTO B. CATTANEO · 2018 to 2026
$1.3M
NIS PROTEINS WITH ALTERED ANION SPECIFICITYR43TR001191 · NCATS · IMANIS LIFE SCIENCES, LLC · PI LECH, PATRYCJA, RUSSELL, STEPHEN J · 2014 to 2014
$164k
NCATS NIH HHS R43 TR001191NCATS NIH HHS R44 TR001191NCI NIH HHS P30 CA015083NIAID NIH HHS T32 AI132165
6 · The paper itself

Abstract

The sodium iodide symporter (NIS) is widely used as a reporter gene to noninvasively monitor the biodistribution and durability of vector-mediated gene expression via gamma scintigraphy, single-photon emission computed tomography (SPECT), and positron-emission tomography (PET). However, the approach is limited by background signal due to radiotracer uptake by endogenous NIS-expressing tissues. In this study, using the SPECT tracer pertechnetate (

Indexed as

Gene ExpressionGenes, ReporterAnimalsDependovirusGenetic VectorsGene Transfer TechniquesMiceMinke WhalePerchloratesPositron-Emission TomographySodium-Iodide SymportersSymportersTissue DistributionTomography, Emission-Computed, Single-PhotonPerchloratesSodium-Iodide SymportersSymportersAAV-9gene therapyimagingNISperchloratePETSLC5A5sodium iodide symporterSPECT

Identifiers

PMID33038323
PMCPMC7791078
OpenAlexW3089808843

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.