Trial reportNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2021
Event-related potential (P300): the effects of levetiracetam in cognitive performance.
Trial report in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- P300 Event-Related Potentials as Cognitive Biomarkers in Neurological and Neuropsychiatric Disorders: A Systematic Review.Revista de neurologia · 2026Pooled it
- Oxytocin facilitates top-down and bottom-up attention to emotional faces in a general and temporal-dependent manner.Psychological medicine · 2026Trial
- Improvement of poststroke cognitive impairment by intermittent theta bursts: A double-blind randomized controlled trial.Brain and behavior · 2022Trial
- Vagus Nerve Stimulation differentially modulates P3b in responders and non-responders: toward a biomarker of therapeutic efficacy.Frontiers in neuroscience · 2026Article
- Executive Function and Transfer Effect Training in Children: A Behavioral and Event-Related Potential Pilot Study.Behavioral sciences (Basel, Switzerland) · 2025Article
- Ginkgo Biloba as a niche theme cognitive enhancer agent, 1420 dokumen of Scopus database. A bibliometric study from 1988 to 2024.F1000Research · 2025Article
- Perceptual information processing in table tennis players: based on top-down hierarchical predictive coding.Cognitive neurodynamics · 2024Article
- Does Transcranial Direct Current Stimulation Affect Potential P300-Related Events in Vascular Dementia? Considerations from a Pilot Study.Biomedicines · 2024Article
- Neural and behavioral evidence for oxytocin's facilitatory effects on learning in volatile and stable environments.Communications biology · 2024Article
- Forensic Study on Objective Evaluation of Visual Acuity of Ametropia with the Event-related Potential P3.Current medical science · 2023Article
- Elderly people with human T-cell leukemia virus type 1-associated myelopathy present an early impairment in cognitive skills.Arquivos de neuro-psiquiatria · 2023Article
- Workflow for health-related and brain data lifecycle.Frontiers in digital health · 2022Review
- Effects of dual-task training in patients with post-stroke cognitive impairment: A randomized controlled trial.Frontiers in neurology · 2022Article
- Behavioral Analysis of EEG Signals in Loss-Gain Decision-Making Experiments.Behavioural neurology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe current study is a reanalysis in the time domain of EEG data collection in healthy adults during an oddball paradigm using levetiracetam (LEV) vs. placebo acute administration. Specifically, the event-related potential (ERP) technique provides a tool for exploring the EEG responses to a specific event/stimulus. One of the ERP components widely studied is the P300 component, which is associated with the last stage of information processing and a general measurement of "cognitive efficiency."
methodsThe sample was composed of thirteen healthy right-handed individuals randomized to participate under two conditions: LEV and placebo. Electrophysiological measures were collected before and after drug intake. We explored the oddball paradigm, which is commonly used with healthy individuals to investigate the stages of information processing.
resultsThe electrophysiological results showed a main effect of condition on P300 amplitude for the frontal (F3, Fz, F4), central (C3, Cz, C4), and parietal electrodes (P3, Pz, P4). The post hoc comparisons (Scheffé's test) demonstrated the significant differences between electrodes. Regarding P300 latency, all regions represented a main effect of condition. A P300 latency reduction was observed during LEV condition compared with placebo.
conclusionOur study observed the ERP component-P300-through the variation of its amplitude and latency to evaluate a supposed higher CNS efficiency when participants were under the LEV effect. Our findings sustain this premise, mainly due to reducing in P300 latency for the LEV condition, supporting the neural efficiency hypothesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.