ArticleActa neurochirurgica2021
Higher oscillatory shear index is related to aneurysm recanalization after coil embolization in posterior communicating artery aneurysms.
Article in Acta neurochirurgica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 12 citations in OpenAlex.
- Endovascular treatment of basilar apex aneurysms: A bi-institutional case series and exploratory pulsatile computational fluid dynamic analysis.Neurosurgical review · 2026Article
- The efficacy of intentional compressed placement of flow diverter stent for improvement of operative results against internal carotid artery and posterior communicating artery bifurcation aneurysms: patient series.Journal of neurosurgery. Case lessons · 2025Article
- In vitro and in silico assessment of flow modulation after deploying the Contour Neurovascular System in intracranial aneurysm models.Journal of neurointerventional surgery · 2024Article
- Early vascular embolization improves neurological function in patients with intracranial aneurysm.American journal of translational research · 2024Article
- Hemodynamic differences of posterior communicating artery aneurysms between adult and fetal types of posterior cerebral artery.Acta neurochirurgica · 2023Article
- Improving the accuracy of computational fluid dynamics simulations of coiled cerebral aneurysms using finite element modeling.Journal of biomechanics · 2023Article
- How does the recurrence-related morphology characteristics of the Pcom aneurysms correlated with hemodynamics?Frontiers in neurology · 2023Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe recurrence rate of posterior communicating artery (Pcom) aneurysms after endovascular treatment (EVT) is higher than that for aneurysms located in other sites. However, it is still unclear what mechanisms are responsible for the recanalization of cerebral aneurysms. In this investigation, we compared hemodynamic factors related with recanalization of Pcom aneurysms treated by endoluminal coiling using computational fluid dynamics (CFD) with high-resolution three-dimensional digital subtraction angiography images.
methodsTwenty patients were enrolled. A double-sinogram acquisition was performed with and without contrast injection after coil embolization to get true blood vessel lumen by relatively complementing the first sinogram with the second. Adaptive Cartesian meshing was performed to produce vascular wall objects for CFD simulation. The boundary condition for inlet (ICA) was set for dynamic velocity according to the cardiac cycle (0.8 s). Hemodynamic parameters were recorded at two specific points (branching point of Pcom and residual sac). The peak pressure, peak WSS, and oscillatory shear index (OSI) were recorded and analyzed.
resultsThe median age was 61.0 years, and 18 patients (90%) were female. During a median follow-up of 12 months, seven (35%) treated aneurysms showed recanalization. The median aneurysm volume was significantly higher, and aneurysm height and neck sizes were significantly longer in the recanalization group than those in the stable group. At the branching point of the Pcom, the peak pressure, peak WSS, or OSI did not significantly differ between the two groups. The only statistically significant hemodynamic parameter related with recanalization was the OSI at the aneurysm point. Multivariate logistic regression showed that with an increase of 0.01 OSI at the aneurysm point, the odds ratio for the aneurysm recanalization was 1.19.
conclusionsA higher OSI is related with recanalization after coil embolization for a Pcom aneurysm.
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