Evidence map›Paper›PMID 33037887›Full record

ArticleDiabetologia2021

Urinary podocyte-derived microparticles in youth with type 1 and type 2 diabetes.

Katie M Sullivan, James Scholey, Rahim Moineddin, Etienne Sochett, Brandy Wicklow, Yesmino Elia, Feng Xiao, Thalia Mederios, Pusha Sadi, Dylan Burger and 2 more

Erratum issuedOpen access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Diabetologia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
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  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Katie M SullivanRenal Electrolyte and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. KatieMarie.Sullivan@pennmedicine.upenn.edu.ORCID 0000-0002-2606-733X
James ScholeyDepartment of Medicine, University of Toronto, Toronto, ON, Canada.ORCID 0000-0001-5591-2267
Rahim MoineddinDepartment of Family and Community Medicine, University of Toronto, Toronto, ON, Canada.ORCID 0000-0002-5506-084X
Etienne SochettDepartment of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Brandy WicklowDepartment of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada.
Yesmino EliaDepartment of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Feng XiaoKidney Research Centre, Department of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.
Thalia MederiosKidney Research Centre, Department of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.
Pusha SadiDepartment of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada.
Dylan BurgerKidney Research Centre, Department of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.ORCID 0000-0003-3951-2911
Farid H MahmudDepartment of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.ORCID 0000-0002-3557-3584
Alison B DartDepartment of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada.ORCID 0000-0002-4718-9408
University of Toronto · CAChildren's Hospital Research Institute of Manitoba · CAUniversity of Ottawa · CAHospital for Sick Children · CAUniversity Health Network · CA

Funding

Canadian Institute of Health Research Operating Grant MOP-343810,
6 · The paper itself

Abstract

aims/hypothesisThe release of podocyte-derived microparticles into the urine may reflect early kidney injury in diabetes. We measured the urinary excretion of podocyte-derived microparticles in youth with type 1 and type 2 diabetes, and related the values to blood pressure, renal function and blood glucose levels.

methodsCross-sectional, exploratory analysis of urine samples and clinical data from youth with type 1 (n = 53) and type 2 (n = 50) diabetes was carried out. Urinary podocyte-derived microparticle numbers, measured by flow cytometry, were assessed in relation to measures of blood glucose levels and renal function.

resultsPodocyte-derived microparticle excretion (MPE) normalised to urinary creatinine (MP/UCr) was higher in type 1 vs type 2 diabetes (median [IQR] MP/UCr: 7.88 [8.97] vs 1.84 [8.62]; p < 0.0001), despite the type 2 diabetes group having higher blood pressure (systolic blood pressure, median [range]: 124 [110-154] vs 114 [94-143] mmHg) and higher proportions of microalbuminuria (44.0% vs 13.2%), but shorter time since diabetes diagnosis (median [range]: 1.2 [0.0-7.0] vs 6.4 [2.0-13.9] years), than the type 1 diabetes cohort. MPE in youth with type 1 diabetes was associated with blood glucose (p = 0.01) and eGFR (p = 0.03) but not HbA CONCLUSIONS/

interpretationSignificant associations between podocyte MPE, blood glucose levels and eGFR were observed in youth with type 1 diabetes but not in those with type 2 diabetes, notwithstanding increased renal pathology in the type 2 diabetes cohort. These findings suggest that podocyte injury differs in the two diabetes cohorts. Graphical abstract.

Indexed as

Acute Kidney InjuryAdolescentBlood GlucoseBlood PressureCell-Derived MicroparticlesCreatinineDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2Diabetic NephropathiesFemaleFlow CytometryGlomerular Filtration RateGlycated HemoglobinHumansMalePodocytesBlood GlucoseCreatinineGlycated Hemoglobinhemoglobin A1c protein, humanAlbuminuriaBlood pressureeGFRHyperglycaemiaMicroparticlesPodocytesType 1 diabetesType 2 diabetesUrineYouth

Identifiers

PMID33037887
OpenAlexW3091813375

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.