ArticleNeuropsychopharmacology reports2020
Use of the Illumina EPIC methylation array for epigenomic research in the crab-eating macaque (Macaca fascicularis).
Article in Neuropsychopharmacology reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 9 citations in OpenAlex.
- Can DNA Methylation Profiling Classify Histologic Subtypes and Grades in Soft Tissue Sarcoma?Clinical orthopaedics and related research · 2024Article
- DNA methylation dynamics and dysregulation delineated by high-throughput profiling in the mouse.Cell genomics · 2022Article
- Decreased DNA methylation at promoters and gene-specific neuronal hypermethylation in the prefrontal cortex of patients with bipolar disorder.Molecular psychiatry · 2021Article
- Use of the Illumina EPIC methylation array for epigenomic research in the crab-eating macaque (Macaca fascicularis).Neuropsychopharmacology reports · 2020Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCommercially available Illumina DNA methylation arrays (HumanMethylation 27K, HumanMethylation450, and MethylationEPIC BeadChip) can be used for comprehensive DNA methylation analyses of not only the human genome but also other mammalian genomes, ranging from those of nonhuman primates to those of rodents. However, practical application of the EPIC array to the crab-eating macaque has not been reported.
methodsThrough bioinformatic analyses involving cross-species comparison and consideration of probe performance, we selected array probes that can be reliably used for the crab-eating macaque genome. A DNA methylation assay using an EPIC array was performed on genomic DNA extracted from the brains of five crab-eating macaques. The obtained DNA methylation data were compared with a publicly available dataset.
resultsAmong the 865 918 probes in the EPIC array, a total of 183 509 probes (21.2%) were selected as high-confidence array probes in the crab-eating macaque. Subsequent comparisons revealed that the data from these probes showed good concordance with other DNA methylation datasets of the crab-eating macaque.
conclusionThe selected high-confidence array probes would be useful for high-throughput DNA methylation assays of the crab-eating macaque.
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