Evidence map›Paper›PMID 33037698›Full record

ReviewPhytotherapy research : PTR2021

Potential roles of medicinal plants for the treatment of viral diseases focusing on COVID-19: A review.

Bikash Adhikari, Bishnu P Marasini, Binod Rayamajhee, Bibek Raj Bhattarai, Ganesh Lamichhane, Karan Khadayat, Achyut Adhikari, Santosh Khanal, Niranjan Parajuli

Abstract readReview
In one paragraph

Review in Phytotherapy research : PTR, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers.

0numbers the graph read from it
0cells of the map it votes in
106citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

106 citing papers in PubMed.

  1. Article
  2. Chemical profiling andFrontiers in nutrition · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Prospects ofHeliyon · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Effect of a Total Extract and Saponins fromInternational journal of molecular sciences · 2023
    Article

46 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bikash AdhikariCentral Department of Chemistry, Tribhuvan University, Kirtipur, Nepal.ORCID https://orcid.org/0000-0002-5532-6644
Bishnu P MarasiniDepartment of Biotechnology, National College, Tribhuvan University, Kirtipur, Nepal.ORCID https://orcid.org/0000-0001-6153-5234
Binod RayamajheeSchool of Optometry and Vision Science, Faculty of Science, University of New South Wales (UNSW), Sydney, Australia.ORCID https://orcid.org/0000-0003-3007-8901
Bibek Raj BhattaraiCentral Department of Chemistry, Tribhuvan University, Kirtipur, Nepal.ORCID https://orcid.org/0000-0003-0259-5004
Ganesh LamichhaneCentral Department of Chemistry, Tribhuvan University, Kirtipur, Nepal.ORCID https://orcid.org/0000-0002-4352-7457
Karan KhadayatCentral Department of Chemistry, Tribhuvan University, Kirtipur, Nepal.ORCID https://orcid.org/0000-0002-8125-9756
Achyut AdhikariCentral Department of Chemistry, Tribhuvan University, Kirtipur, Nepal.ORCID https://orcid.org/0000-0002-1065-5727
Santosh KhanalDepartment of Biotechnology, National College, Tribhuvan University, Kirtipur, Nepal.ORCID https://orcid.org/0000-0002-0186-6119
Niranjan ParajuliCentral Department of Chemistry, Tribhuvan University, Kirtipur, Nepal.ORCID https://orcid.org/0000-0002-9233-6489

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The whole world is entangled by the coronavirus disease (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), people are dying in thousands each day, and without an actual medication, it seems not possible for the bringing this global health crisis to a stop. Natural products have been in constant use since ancient times and are proven by time to be effective. Crude extract or pure compounds isolated from medicinal plants and/or herbs such as Artemisia annua, Agastache rugosa, Astragalus membranaceus, Cassia alata, Ecklonia cava, Gymnema sylvestre, Glycyrrhizae uralensis, Houttuynia cordata, Lindera aggregata, Lycoris radiata, Mollugo cerviana, Polygonum multiflorum, Pyrrosia lingua, Saposhnikoviae divaricate, Tinospora cordifolia etc. have shown promising inhibitory effect against coronavirus. Several molecules, including acacetin, amentoflavone, allicin, blancoxanthone, curcumin, daidzein, diosmin, epigallocatechin-gallate, emodin, hesperidin, herbacetin, hirsutenone, iguesterin, jubanine G, kaempferol, lycorine, pectolinarin, phloroeckol, silvestrol, tanshinone I, taxifolin, rhoifolin, xanthoangelol E, zingerol etc. isolated from plants could also be potential drug candidates against COVID-19. Moreover, these could also show promising inhibitory effects against influenza-parainfluenza viruses, respiratory syncytial virus, severe acute respiratory syndrome (SARS), and Middle East respiratory syndrome coronavirus (MERS-CoV). Here, we have reported 93 antiviral drug candidates which could be a potential area of research in drug discovery.

Indexed as

COVID-19 Drug TreatmentAntiviral AgentsHumansMiddle East Respiratory Syndrome CoronavirusPandemicsPhytochemicalsPlants, MedicinalSARS-CoV-2Antiviral AgentsPhytochemicalsanti-antiviral activity and COVID-19drug candidatesnatural products

Identifiers

PMID33037698
PMCPMC7675695

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.