Evidence map›Paper›PMID 33037618›Full record

ArticleBritish journal of pharmacology2021

NH-sulfoximine: A novel pharmacological inhibitor of the mitochondrial F

Daniela Strobbe, Rosalba Pecorari, Oriana Conte, Antonella Minutolo, Christine M M Hendriks, Stefan Wiezorek, Danilo Faccenda, Rosella Abeti, Carla Montesano, Carsten Bolm and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Antioxidant Phytocomplexes Extracted from Pomegranate (Antioxidants (Basel, Switzerland) · 2023
    Article
  4. Article
  5. ATPase Inhibitory Factor-1 Disrupts Mitochondrial CaInternational journal of molecular sciences · 2021
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Daniela StrobbeDepartment of Biology, University of Rome "Tor Vergata", Rome, Italy.ORCID 0000-0003-3000-5892
Rosalba PecorariDepartment of Biology, University of Rome "Tor Vergata", Rome, Italy.
Oriana ConteDepartment of Biology, University of Rome "Tor Vergata", Rome, Italy.
Antonella MinutoloDepartment of Cell and Developmental Biology, Consortium for Mitochondrial Research (CfMR), University College London, London, UK.
Christine M M HendriksInstitute of Organic Chemistry, RWTH Aachen University, Aachen, Germany.
Stefan WiezorekInstitute of Organic Chemistry, RWTH Aachen University, Aachen, Germany.
Danilo FaccendaDepartment of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, London, UK.
Rosella AbetiAtaxia Centre, Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Queen Square London, London, WC1N 3BG, UK.ORCID 0000-0001-9817-8779
Carla MontesanoDepartment of Biology, University of Rome "Tor Vergata", Rome, Italy.
Carsten BolmInstitute of Organic Chemistry, RWTH Aachen University, Aachen, Germany.
Michelangelo CampanellaDepartment of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, London, UK.ORCID 0000-0002-6948-4184
University of Rome Tor Vergata · ITRWTH Aachen University · DEQueen Mary University of London · GBUniversity College London · GBUniversity of London · GB

Funding

AIRC-MFAG 21903Biotechnology and Biological Sciences Research Council BB/M010384/1Biotechnology and Biological Sciences Research Council BB/N007042/1European Research Council Consolidator Grant COG 2018-819600_FIRMFIRB-Research Grant Consolidator Grant 2 RBFR13P392Italian Ministry of Health IFO14/01/R/52LAM-Bighi Grant Initiative
6 · The paper itself

Abstract

background and purposeThe mitochondrial F EXPERIMENTAL APPROACH: The chemical structure of the F KEY

resultsNHS selectively blocks the consumption of ATP by mitochondria leading a subtle cytotoxicity associated via the concomitant engagement of autophagy which impairs cell viability. NHS achieves such a function independently of the F CONCLUSION AND IMPLICATIONS: The novel sulfoximine analogue of BTB-06584, NHS, acts as a selective pharmacological inhibitor of the mitochondrial F

Indexed as

MitochondriaProton-Translocating ATPasesAdenosine TriphosphateCell DeathHumansHydrolysisAdenosine TriphosphateProton-Translocating ATPasesAutophagycell deathF1Fo-ATPsynthaseIF1mitochondria

Identifiers

PMID33037618
PMCPMC9328437
OpenAlexW3092390987

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.