Observational studyJournal of endocrinological investigation2021
Primary hyperparathyroidism in pregnancy: observations from the Indian PHPT registry.
Observational study in Journal of endocrinological investigation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Comparison between surgical and non-surgical management of primary hyperparathyroidism during pregnancy: a systematic review.Endocrine · 2024Pooled it
- Parathyroid adenoma in pregnancy: A case report and systematic review of the literature.Frontiers in endocrinology · 2022Pooled it
- Management of Chronic Hypoparathyroidism and Hyperparathyroidism in Pregnancy/Lactation.Current osteoporosis reports · 2026Review
- Ultrasound-guided microwave ablation for primary hyperparathyroidism in a pregnancy patient with medullary sponge kidney: a case description and literature analysis.Quantitative imaging in medicine and surgery · 2026Article
- Gestational hypercalcemia: a narrative review of literature.Frontiers in medicine · 2026Review
- Challenges in the management of jaw tumor syndrome: a case report of pregnancy complicating treatment decision making.Endocrinology, diabetes & metabolism case reports · 2025Article
- Primary hyperparathyroidism during pregnancy: ultrasound as an accurate preoperative localization imaging modality.Orphanet journal of rare diseases · 2025Article
- Disorders of bone and mineral metabolism in pregnancy and lactation: A case based clinical review.Osteoporosis and sarcopenia · 2025Review
- Pregnancy Complicated by Primary Hyperparathyroidism-A Case Report on the Use of Cinacalcet.Clinical case reports · 2025Article
- Potential benefits of intraoperative parathyroid autofluorescence imaging in a patient with multiple endocrine neoplasia type 1 and hyperparathyroidism - A case report.International journal of surgery case reports · 2025Article
- Turning Points in Cross-Disciplinary Perspective of Primary Hyperparathyroidism and Pancreas Involvements: Hypercalcemia-Induced Pancreatitis,International journal of molecular sciences · 2024Review
- Case report: Microwave ablation is a safe and effective method for primary hyperparathyroidism in pregnancy.Frontiers in medicine · 2024Article
- Association of hypertension in pregnancy with serum electrolyte disorders in late pregnancy among Cameroonian women.Scientific reports · 2023Article
- Expert consensus on multidisciplinary approach to the diagnosis and treatment of primary hyperparathyroidism in pregnancy in China.Endocrine · 2023Article
- Approach to the Patient: Management of Parathyroid Diseases Across Pregnancy.The Journal of clinical endocrinology and metabolism · 2023Article
- Calcium, Potassium, Sodium, and Magnesium Concentrations in the Placenta, Umbilical Cord, and Fetal Membrane from Women with Multiple Pregnancies.Life (Basel, Switzerland) · 2023Article
- Parathyroid carcinoma-related severe acute pancreatitis during pregnancy: a case report and literature review.Gastroenterology report · 2023Article
- Revisiting Captain Charles Martell: witnessing the true face of primary hyperparathyroidism even in the twenty-first century.Archives of osteoporosis · 2022Article
- European Expert Consensus on Practical Management of Specific Aspects of Parathyroid Disorders in Adults and in Pregnancy: Recommendations of the ESE Educational Program of Parathyroid Disorders.European journal of endocrinology · 2022Article
- Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo present the data on primary hyperparathyroidism (PHPT) in pregnancy from India obtained from a large database maintained over 15 years.
methodsWe retrieved data of all women with gestational PHPT from the Indian PHPT registry between July 2005 and January 2020, and compared their clinical, biochemical, and other characteristics with age-matched non-pregnant women with PHPT.
resultsOut of 386 women, eight had gestational PHPT (2.1%). The common presenting manifestations were acute pancreatitis (50%) and renal stone disease (50%); two were asymptomatic. Five women (62.5%) had a history of prior miscarriages. Seven patients (88%) had preeclampsia during the present gestation. Serum calcium and intact parathyroid hormone (iPTH) were not statistically different from the age-matched non-pregnant PHPT group. Six patients with mild-to-moderate hypercalcemia were medically managed with hydration with/without cinacalcet while one patient underwent percutaneous ethanol ablation of the parathyroid adenoma; none underwent surgery during pregnancy. Mean serum calcium maintained from treatment initiation till delivery was 10.5 ± 0.4 mg/dl. One patient had spontaneous preterm delivery at 36 weeks; the remaining patients had normal vaginal delivery at term. None had severe preeclampsia/eclampsia. Fetal outcomes included low birth weight in three newborns (37.5%); two of them had hypocalcemic seizures.
conclusionThe prevalence of gestational PHPT was 2.1% in this largest Indian PHPT cohort, which is higher than that reported from the West (< 1%). Gestational PHPT can lead to preeclampsia and miscarriage. Pregnant PHPT patients with mild-to-moderate hypercalcemia can be managed with hydration/cinacalcet; however, long-term safety data and large-scale randomized controlled trials are required.
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