SynthesisNeurosurgical review2021
Outcomes of deep brain stimulation surgery for substance use disorder: a systematic review.
Synthesis in Neurosurgical review, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Neuroplasticity and recovery of the brain affected by substance use disorder: multilevel mechanisms and new therapeutic strategies (2020-2025).Frontiers in molecular neuroscience · 2026Pooled it
- Effects of deep brain stimulation of the nucleus accumbens and anterior limb of the internal capsule on heroin addiction: Over five years of long-term follow-up in a prospective open-label pilot study.Translational psychiatry · 2025Article
- Invasive and Non-Invasive Neuromodulation for the Treatment of Substance Use Disorders: A Review of Reviews.Brain sciences · 2025Review
- Biomarkers: The Key to Enhancing Deep Brain Stimulation Treatment for Psychiatric Conditions.Brain sciences · 2024Review
- Harnessing the sensing and stimulation function of deep brain-machine interfaces: a new dawn for overcoming substance use disorders.Translational psychiatry · 2024Review
- Non-invasive suppression of the human nucleus accumbens (NAc) with transcranial focused ultrasound (tFUS) modulates the reward network: a pilot study.Frontiers in human neuroscience · 2024Article
- Nucleus accumbens D1/D2 circuits control opioid withdrawal symptoms in mice.The Journal of clinical investigation · 2023Article
- Could deep brain stimulation be a possible solution for acquired hypothalamic obesity?Heliyon · 2023Review
- Cell type and sex specific insights into ventral striatum deep brain stimulation for cocaine relapse.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Are We Getting High Cause the Thrill is Gone?Journal of addiction psychiatry · 2023Article
- Therapeutic potential of brain stimulation techniques in the treatment of mental, psychiatric, and cognitive disorders.CNS neuroscience & therapeutics · 2023Review
- Opioid use disorder: current trends and potential treatments.Frontiers in public health · 2023Review
- Deep brain stimulation of the nucleus accumbens in the treatment of severe alcohol use disorder: a phase I pilot trial.Molecular psychiatry · 2022Article
- Brain tract structure predicts relapse to stimulant drug use.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Neuroscientific Basis of Treatment for Substance Use Disorders.Noro psikiyatri arsivi · 2022Review
- Deep brain stimulation for psychiatric disorders: role of imaging in identifying/confirming DBS targets, predicting, and optimizing outcome and unravelling mechanisms of action.Psychoradiology · 2021Article
- The utility of deep brain stimulation surgery for treating eating disorders: A systematic review.Surgical neurology international · 2021Review
- Endocannabinoid Modulation of Nucleus Accumbens Microcircuitry and Terminal Dopamine Release.Frontiers in synaptic neuroscience · 2021Review
- The potential of brain stimulation techniques for substance use disorder treatment.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Long has the standard of care for substance use disorder (SUD) been pharmacotherapy, psychotherapy, or rehabilitation with varying success. Deep brain stimulation (DBS) may have a beneficial reduction in the addiction-reward pathway. Recent studies have found reduced relapse and improvements in quality of life following DBS stimulation of the nucleus accumbens. We aim to identify positive outcomes and adverse effects to assess the viability of DBS as a treatment of addiction. A PubMed search following PRISMA guidelines was conducted to identify the entirety of reports reporting DBS as a treatment for SUD. Outcomes were extracted from the literature to be summarized, and a review of the quality of publications was also performed. From 2305 publications, 14 studies were found to fit the inclusion criteria published between 2007 and 2019. All studies targeted the nucleus accumbens (NAc) and remission rates at 6 months, 1 year, 2 years, and more than 6 years were 61% (20/33), 53% (17/32), 43% (14/30), and 50% (3/6), respectively. Not all studies detailed the stimulation settings or coordinates. The most common adverse effect across studies was a weight change of at least 2 kg. DBS shows potential as a long-term treatment of SUD in refractory patients. Further studies with controlled double-blind paradigms are needed for evaluation of the efficacy and safety of this treatment. Future studies should also investigate other brain regions for stimulation and optimal device stimulation parameters.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.