ReviewNature reviews. Cardiology2021
Lifestyle interventions for the prevention and treatment of hypertension.
Review in Nature reviews. Cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 206 papers, 16 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
206 citing papers in PubMed, 16 syntheses or guidelines pooled it, 339 citations in OpenAlex.
- Pooled it
- Exercise-induced changes in systemic inflammatory biomarkers in overweight and obese populations: a bibliometric analysis and umbrella review of meta-analyses.Frontiers in immunology · 2026Pooled it
- Pooled it
- Correlation analysis of systemic immune inflammation index with the occurrence and clinical outcomes of hypertension: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2025Pooled it
- An updated network meta-analysis of non-pharmacological interventions for primary hypertension in adults: insights from recent studies.Systematic reviews · 2024Pooled it
- EPA guidance on lifestyle interventions for adults with severe mental illness: A meta-review of the evidence.European psychiatry : the journal of the Association of European Psychiatrists · 2024Pooled it
- The Microbial Perspective: A Systematic Literature Review on Hypertension and Gut Microbiota.Nutrients · 2024Pooled it
- Effects of aerobic exercise on blood pressure in patients with hypertension: a systematic review and dose-response meta-analysis of randomized trials.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Pooled it
- Effect of vitamin BBMJ open · 2024Pooled it
- Does dance therapy benefit the improvement of blood pressure and blood lipid in patients with hypertension? A systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2024Pooled it
- Gut microbiota changes in patients with hypertension: A systematic review and meta-analysis.Journal of clinical hypertension (Greenwich, Conn.) · 2023Pooled it
- Overview of hypertension in Saudi Arabia: A systematic review and meta-analysis.Saudi medical journal · 2023Pooled it
- Efficacy of Dietary Polyphenols from Whole Foods and Purified Food Polyphenol Extracts in Optimizing Cardiometabolic Health: A Meta-Analysis of Randomized Controlled Trials.Advances in nutrition (Bethesda, Md.) · 2023Pooled it
- Care Cascades for Hypertension in Low-Income Settings: A Systematic Review and Meta-Analysis.International journal of public health · 2023Pooled it
- Is resistance training alone an antihypertensive therapy? A meta-analysis.Journal of human hypertension · 2021Pooled it
- Healthcare professional-led interventions on lifestyle modifications for hypertensive patients - a systematic review and meta-analysis.BMC family practice · 2021Pooled it
- Adequate Vegetable Intake Improves Metabolic Indices in Healthy Japanese Participants: A Randomized Crossover Study.Journal of atherosclerosis and thrombosis · 2025Trial
- The effects of a digital lifestyle intervention in patients with hypertension: Results of a pilot randomized controlled trial.Journal of clinical hypertension (Greenwich, Conn.) · 2024Trial
- The Effect of an mHealth Self-Monitoring Intervention (MI-BP) on Blood Pressure Among Black Individuals With Uncontrolled Hypertension: Randomized Controlled Trial.JMIR mHealth and uHealth · 2024Trial
- Risk of sleep apnea associated with higher blood pressure among Chinese and Korean Americans.Ethnicity & health · 2024Trial
146 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypertension affects approximately one third of the world's adult population and is a major cause of premature death despite considerable advances in pharmacological treatments. Growing evidence supports the use of lifestyle interventions for the prevention and adjuvant treatment of hypertension. In this Review, we provide a summary of the epidemiological research supporting the preventive and antihypertensive effects of major lifestyle interventions (regular physical exercise, body weight management and healthy dietary patterns), as well as other less traditional recommendations such as stress management and the promotion of adequate sleep patterns coupled with circadian entrainment. We also discuss the physiological mechanisms underlying the beneficial effects of these lifestyle interventions on hypertension, which include not only the prevention of traditional risk factors (such as obesity and insulin resistance) and improvements in vascular health through an improved redox and inflammatory status, but also reduced sympathetic overactivation and non-traditional mechanisms such as increased secretion of myokines.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.