Evidence map›Paper›PMID 33037325›Full record

ReviewNature reviews. Cardiology2021

Integration of novel monitoring devices with machine learning technology for scalable cardiovascular management.

Chayakrit Krittanawong, Albert J Rogers, Kipp W Johnson, Zhen Wang, Mintu P Turakhia, Jonathan L Halperin, Sanjiv M Narayan

Registry-linked trialOpen access · bronzeAbstract readReview
In one paragraph

Review in Nature reviews. Cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06993415 (Optimize Risk Prediction After Myocardial Infarction Through Artificial Intelligence and Multidimensional Evaluation), which is not on this map. Cited by 96 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed, 2 pooled it
16.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06993415 recruitingnot on this mapstarted 2025, after this paper: background citation

Optimize Risk Prediction After Myocardial Infarction Through Artificial Intelligence and Multidimensional Evaluation: The ORACLE Study

TypeobservationalSponsorFundación Pública Andaluza para la Investigación de Málaga en Biomedicina y SaludRan2025 to 2028Enrolled750ConditionsMyocardial Infarction (MI)Armsdata collection
3 · Its place in the literature

Who cites it

96 citing papers in PubMed, 2 syntheses or guidelines pooled it, 221 citations in OpenAlex.

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36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 1 country.

Chayakrit Krittanawong *Section of Cardiology, Baylor College of Medicine, Houston, TX, USA. chayakrit.krittanawong@bcm.edu.ORCID http://orcid.org/0000-0001-7953-335X
Albert J Rogers *Department of Medicine and Cardiovascular Institute, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-6585-534X
Kipp W JohnsonInstitute for Next Generation Healthcare, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-5102-741X
Zhen WangRobert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN, USA.
Mintu P TurakhiaVA Palo Alto Health Care System, Palo Alto, CA, USA.
Jonathan L HalperinThe Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, Mount Sinai Medical Center, New York, NY, USA.
Sanjiv M NarayanDepartment of Medicine and Cardiovascular Institute, Stanford University, Stanford, CA, USA. sanjiv1@stanford.edu.
Cardiovascular Institute of the South · USBaylor College of Medicine · USIcahn School of Medicine at Mount Sinai · USMayo Clinic in Arizona · USMount Sinai Medical Center · USVA Palo Alto Health Care System · US

Funding

The Dynamics of Human Atrial FibrillationR01HL083359 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Sanjiv M Narayan · 2008 to 2026
$7.9M
Machine Learning in Atrial FibrillationR01HL149134 · NHLBI · STANFORD UNIVERSITY · PI NARAYAN, SANJIV M · 2020 to 2024
$3.8M
NHLBI NIH HHS R01 HL083359NHLBI NIH HHS R01 HL149134
6 · The paper itself

Abstract

Ambulatory monitoring is increasingly important for cardiovascular care but is often limited by the unpredictability of cardiovascular events, the intermittent nature of ambulatory monitors and the variable clinical significance of recorded data in patients. Technological advances in computing have led to the introduction of novel physiological biosignals that can increase the frequency at which abnormalities in cardiovascular parameters can be detected, making expert-level, automated diagnosis a reality. However, use of these biosignals for diagnosis also raises numerous concerns related to accuracy and actionability within clinical guidelines, in addition to medico-legal and ethical issues. Analytical methods such as machine learning can potentially increase the accuracy and improve the actionability of device-based diagnoses. Coupled with interoperability of data to widen access to all stakeholders, seamless connectivity (an internet of things) and maintenance of anonymity, this approach could ultimately facilitate near-real-time diagnosis and therapy. These tools are increasingly recognized by regulatory agencies and professional medical societies, but several technical and ethical issues remain. In this Review, we describe the current state of cardiovascular monitoring along the continuum from biosignal acquisition to the identification of novel biosensors and the development of analytical techniques and ultimately to regulatory and ethical issues. Furthermore, we outline new paradigms for cardiovascular monitoring.

Indexed as

Cardiovascular DiseasesMachine LearningMonitoring, AmbulatoryHumansWearable Electronic Devices

Identifiers

PMID33037325
PMCPMC7545156
OpenAlexW3092371431

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.