Evidence map›Paper›PMID 33037294›Full record

ArticleScientific reports2020

Two genetic variants explain the association of European ancestry with multiple sclerosis risk in African-Americans.

Nathan Nakatsuka, Nick Patterson, Nikolaos A Patsopoulos, Nicolas Altemose, Arti Tandon, Ashley H Beecham, Jacob L McCauley, Noriko Isobe, Stephen Hauser, Philip L De Jager and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. GWAS highlights the neuronal contribution to multiple sclerosis susceptibility.medRxiv : the preprint server for health sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Nathan NakatsukaDepartment of Genetics, Harvard Medical School, New Research Building, Boston, MA, 02115, USA. nathan_nakatsuka@hms.harvard.edu.
Nick PattersonDepartment of Human Evolutionary Biology, Harvard University, 16 Divinity Ave., Cambridge, MA, 02138, USA.
Nikolaos A PatsopoulosBroad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, 02141, USA.
Nicolas AltemoseDepartment of Bioengineering, University of California Berkeley, San Francisco, Berkeley, CA, 94720, USA.
Arti TandonDepartment of Genetics, Harvard Medical School, New Research Building, Boston, MA, 02115, USA.
Ashley H BeechamJohn P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, 33136, USA.
Jacob L McCauleyJohn P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, 33136, USA.
Noriko IsobeDepartment of Neurology, University of California San Francisco School of Medicine, San Francisco, CA, 94158, USA.
Stephen HauserDepartment of Neurology, University of California San Francisco School of Medicine, San Francisco, CA, 94158, USA.
Philip L De JagerBroad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, 02141, USA.
David A HaflerBroad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, 02141, USA.
Jorge R OksenbergDepartment of Neurology, University of California San Francisco School of Medicine, San Francisco, CA, 94158, USA.
David ReichDepartment of Genetics, Harvard Medical School, New Research Building, Boston, MA, 02115, USA. reich@genetics.med.harvard.edu.
Broad Institute · USUniversity of California, San Francisco · USUniversity of Miami · USHarvard University · USKyushu University · JPUniversity of California, Berkeley · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Medical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0M
Methods for Genome-wide Association Studies in Admixed PopulationsR01HG006399 · NHGRI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI PRICE, ALKES L · 2011 to 2024
$6.3M
Genetic and Phenotypic Analysis of Multiple Sclerosis in HispanicsR01NS096212 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI MCCAULEY, JACOB L · 2016 to 2021
$3.1M
Howard Hughes Medical InstituteMultiple Sclerosis Society RG-1707-28657NCATS NIH HHS UL1 TR001863NHGRI NIH HHS R01 HG006399NIGMS NIH HHS GM007753NIGMS NIH HHS T32 GM007753NIH HHS HG006399NINDS NIH HHS R01 NS096212
6 · The paper itself

Abstract

Epidemiological studies have suggested differences in the rate of multiple sclerosis (MS) in individuals of European ancestry compared to African ancestry, motivating genetic scans to identify variants that could contribute to such patterns. In a whole-genome scan in 899 African-American cases and 1155 African-American controls, we confirm that African-Americans who inherit segments of the genome of European ancestry at a chromosome 1 locus are at increased risk for MS [logarithm of odds (LOD) = 9.8], although the signal weakens when adding an additional 406 cases, reflecting heterogeneity in the two sets of cases [logarithm of odds (LOD) = 2.7]. The association in the 899 individuals can be fully explained by two variants previously associated with MS in European ancestry individuals. These variants tag a MS susceptibility haplotype associated with decreased CD58 gene expression (odds ratio of 1.37; frequency of 84% in Europeans and 22% in West Africans for the tagging variant) as well as another haplotype near the FCRL3 gene (odds ratio of 1.07; frequency of 49% in Europeans and 8% in West Africans). Controlling for all other genetic and environmental factors, the two variants predict a 1.44-fold higher rate of MS in European-Americans compared to African-Americans.

Indexed as

Black or African AmericanFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHaplotypesHumansMaleMultiple SclerosisOdds RatioPolymorphism, Single NucleotideWhite People

Identifiers

PMID33037294
PMCPMC7547691
OpenAlexW3091832666

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.