Evidence map›Paper›PMID 33037249›Full record

ArticleScientific reports2020

Pathophysiology of high fat diet induced obesity: impact of probiotic banana juice on obesity associated complications and hepatosteatosis.

Prabhakar Yellanur Konda, Vijayakumar Poondla, Krishna Kumar Jaiswal, Sreenivasulu Dasari, Reddemma Uyyala, Venkata Prasad Surtineni, Janardhan Yadav Egi, Anthony Johnson Antony Masilamani, Lakshmi Bestha, Sreenath Konanki and 9 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 10 institutions in 2 countries.

Prabhakar Yellanur Konda *Department of Biochemistry, Krijan Biotech, Malleshwaram, Bangalore, India. prabhakaryk@gmail.com.
Vijayakumar PoondlaDepartment of Chemistry, Indian Institute of Technology Hyderabad, Sangareddy, India.
Krishna Kumar JaiswalDepartment of Chemistry, Uttaranchal University, Dehradun, India.
Sreenivasulu DasariDepartment of Biochemistry, Sri Venkateswara University, Tirupati, India.
Reddemma UyyalaDepartment of Biochemistry, Krijan Biotech, Malleshwaram, Bangalore, India.
Venkata Prasad SurtineniDepartment of Biochemistry, Sri Venkateswara University, Tirupati, India.
Janardhan Yadav EgiDepartment of Biotechnology, Sri Venkateswara University, Tirupati, India.
Anthony Johnson Antony MasilamaniDepartment of Botany, Sri Krishnadevaraya University, Anantapur, India.
Lakshmi BesthaDepartment of Zoology, Sri Krishnadevaraya University, Anantapur, India.
Sreenath KonankiDepartment of Biotechnology, Sri Krishnadevaraya University, Anantapur, India.
Muthukumaran MuthulingamDepartment of Ecology and Environmental Sciences, Pondicherry University, Puducherry, India.
Lakshman Kumar LingamguntaDepartment of Biochemistry, Sri Venkateswara University, Tirupati, India.
Bindu Prasuna AloorDepartment of Botany, Rayalaseema University, Kurnool, India.
Sridevi TirumalarajuMahatma Gandhi National Institute of Research and Social Action, Banjara Hills, Hyderabad, India.
Ankanna SadeDepartment of Botany, Sri Venkateswara University, Tirupati, India.
Venkata Ratnam KamsalaDepartment of Botany, Rayalaseema University, Kurnool, India.
Sreeharsha NagarajaDepartment of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Saudi Arabia.
Ranjani RamakrishnanDepartment of Virology, Sri Venkateswara University, Tirupati, India.
Vijayakumar Natesan *Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar, Chidambaram, India. nvkbiochem@yahoo.co.in.
Sri Venkateswara University · INSri Krishnadevaraya University · INRayalaseema University · INAnnamalai University · INBiotech Park · INIndian Institute of Technology Hyderabad · INKing Faisal University · SAPondicherry University · INSri Padmavati Mahila Visvavidyalayam · INUttaranchal University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The high fat diet alters intestinal microbiota due to increased intestinal permeability and susceptibility to microbial antigens leads to metabolic endotoxemia. But probiotic juices reported for various health benefits. In this background we hypothesized that pectinase treated probiotic banana juice has diverse effects on HFD induced obesity and non-alcoholic steatohepatitis. 20 weeks fed HFD successfully induced obesity and its associated complications in experimental rats. The supplementation of probiotic banana juice for 5 months at a dose of 5 mL/kg bw/day resulted significant decrease (p < 0.05) in body weight (380 ± 0.34), total fat (72 ± 0.8), fat percentage (17 ± 0.07) and fat free mass (165 ± 0.02). Reduction (p < 0.05) in insulin resistance (5.20 ± 0.03), lipid profile (TC 120 ± 0.05; TG 160 ± 0.24; HDL 38 ± 0.03), liver lipid peroxidation (0.7 ± 0.01), hepatic enzyme markers (AST 82 ± 0.06; ALT 78 ± 0.34; ALP 42 ± 0.22), and hepatic steatosis by increasing liver antioxidant potential (CAT 1.4 ± 0.30; GSH 1.04 ± 0.04; SOD 0.82 ± 0.22) with normal hepatic triglycerides (15 ± 0.02) and glycogen (0.022 ± 0.15) contents and also showed normal liver size, less accumulation of lipid droplets with only a few congestion. It is concluded that the increased intestinal S. cerevisiae yeast can switch anti-obesity, antidiabetic, antioxidative stress, antioxidant and anti-hepatosteatosis effect. This study results will have significant implications for treatment of NAFLD.

Indexed as

AnimalsAntioxidantsBody WeightDiet, High-FatFatty LiverFruit and Vegetable JuicesInsulin ResistanceLipid MetabolismLipid PeroxidationLipidsLiverMaleMusaNon-alcoholic Fatty Liver DiseaseObesityOxidative StressAntioxidantsLipidsTriglycerides

Identifiers

PMID33037249
PMCPMC7547728
OpenAlexW3091771935

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.