ArticleScientific reports2020
Identification and characterization of mutations responsible for the β-lactam resistance in oxacillin-susceptible mecA-positive Staphylococcus aureus.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 52 citations in OpenAlex.
- Genomic investigation and clinical correlates of theAntimicrobial agents and chemotherapy · 2024Trial
- An Achilles' heel for methicillin-resistantAntimicrobial agents and chemotherapy · 2026Review
- Mutations in RNA polymerase that drive the emergence of antibiotic resistance.Current opinion in microbiology · 2026Review
- Vancomycin MIC creep and the emergence of oxacillin-susceptible MRSA: A three-year surveillance study from a tertiary care centre.New microbes and new infections · 2026Article
- Methicillin-ResistantMicroorganisms · 2026Review
- Compressive pangenomics using mutation-annotated networks.Nature genetics · 2026Article
- Network analysis of antimicrobial resistance inNAR genomics and bioinformatics · 2025Article
- α-Pinene and β-Pinene as Natural Adjuvants Against MRSA: Evidence from in vivo Models and Molecular Docking.Current microbiology · 2025Article
- Evolution of beta-lactam resistance causes fitness reductions and several cases of collateral sensitivities in the human pathogenAntimicrobial agents and chemotherapy · 2025Article
- Efficacy of Essential Oil of Algrizea minor Sobral, Faria & Proença (Myrtaceae) in Combating Methicillin-resistant Staphylococcus aureus: Antibacterial and Virulence Modulation Studies Conducted In Vitro and In Vivo.Chemistry & biodiversity · 2025Article
- Microbubble-Controlled Delivery of Biofilm-Targeting Nanoparticles to Treat MRSA Infection.Advanced functional materials · 2025Article
- Biofilm formation, methicillin resistance and SCCmec types among Staphylococcus aureus isolated from clinical samples from a tertiary care hospital, in Nepal.BMC infectious diseases · 2025Article
- Public health implications of multidrugresistant and methicillinresistant Staphylococcus aureus in retail oysters.Scientific reports · 2025Article
- Multilocus sequence type analysis of coagulase-negative staphylococci from the neonatal intensive care unit of a teaching hospital in Ghana.The Pan African medical journal · 2025Article
- Phagemid-based capsid system for CRISPR-Cas13a antimicrobials targeting methicillin-resistant Staphylococcus aureus.Communications biology · 2024Article
- Phenotypic and genotypic characteristics of mecA - positive oxacillin-sensitive Staphylococcus aureus isolated from patients with bloodstream infection in a tertiary hospital in Southern Brazil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Efficient synthesis of CRISPR-Cas13a-antimicrobial capsids against MRSA facilitated by silent mutation incorporation.Scientific reports · 2024Article
- Article
- The Spx stress regulator confers high-level β-lactam resistance and decreases susceptibility to last-line antibiotics in methicillin-resistantAntimicrobial agents and chemotherapy · 2024Article
- Phenotypic and genomic characteristics of oxacillin-susceptible mecA-positive Staphylococcus aureus, rapid selection of high-level resistance to beta-lactams.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2023Article
Corrections and comments
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Authors and funding
17 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Staphylococcus aureus strains that are susceptible to the β-lactam antibiotic oxacillin despite carrying mecA (OS-MRSA) cause serious clinical problems globally because of their ability to easily acquire β-lactam resistance. Understanding the genetic mechanism(s) of acquisition of the resistance is therefore crucial for infection control management. For this purpose, a whole-genome sequencing-based analysis was performed using 43 clinical OS-MRSA strains and 100 mutants with reduced susceptibility to oxacillin (MICs 1.0-256 µg/mL) generated from 26 representative OS-MRSA strains. Genome comparison between the mutants and their respective parent strains identified a total of 141 mutations in 46 genes and 8 intergenic regions. Among them, the mutations are frequently found in genes related to RNA polymerase (rpoBC), purine biosynthesis (guaA, prs, hprT), (p)ppGpp synthesis (rel
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