ArticleNature communications2020
Brain disconnections link structural connectivity with function and behaviour.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 113 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
113 citing papers in PubMed, 1 synthesis or guideline pooled it, 227 citations in OpenAlex.
- White matter variability, cognition, and disorders: a systematic review.Brain structure & function · 2022Pooled it
- Anatomical white matter tracts span the cortical hierarchy to support cognitive diversity.Nature human behaviour · 2026Article
- Cognition disconnected: the influence of domain-general cognition (g) in lesion-deficit mapping.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Longitudinal Degeneration of Microstructural and Structural Connectivity Patterns Following Stroke.Stroke · 2026Article
- Mapping the functional connectome between grey matter and white matter.Communications biology · 2026Article
- The degenerome-a novel streamline-wise approach for white matter integrity in neurodegeneration.NPJ Parkinson's disease · 2026Article
- Manifold lateralisation and variability in the language connectome at 7T.Research square · 2026Article
- Null models for lesion network mapping.Nature neuroscience · 2026Article
- Investigating the methodological foundation of lesion network mapping.Nature neuroscience · 2026Article
- Bridging Continuous and Discrete Models of the Anterior Temporal Lobe via Cortical Gradients.Research square · 2026Article
- The average does not represent the individual: White matter variability across the brain, across the population, and across the lifespan.Research square · 2026Article
- Cross-species lesion mapping links a midbrain circuit to vergence dysfunction.Brain : a journal of neurology · 2026Article
- Traumatic brain injury and neurological stealth syndromes.Frontiers in neuroscience · 2026Article
- Dissecting the Sublexical Route for Reading: Frontal and Parietal Networks Support Learned Orthography-to-Phonology Mappings.Neurobiology of language (Cambridge, Mass.) · 2026Article
- Stroke recovery beyond initial severity: the complementary roles of brain structure and brain function in acute stroke.Brain communications · 2026Article
- Anatomical White Matter Tracts Span the Cortical Hierarchy to Support Cognitive Diversity.bioRxiv : the preprint server for biology · 2025Article
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- Cognition Disconnected: The Influence of Domain-General Cognition (g) in Lesion-Deficit Mapping.bioRxiv : the preprint server for biology · 2025Article
- Extension of voxel-based lesion mapping to multidimensional neurophysiological data.Scientific reports · 2025Article
53 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Brain lesions do not just disable but also disconnect brain areas, which once deprived of their input or output, can no longer subserve behaviour and cognition. The role of white matter connections has remained an open question for the past 250 years. Based on 1333 stroke lesions, here we reveal the human Disconnectome and demonstrate its relationship to the functional segregation of the human brain. Results indicate that functional territories are not only defined by white matter connections, but also by the highly stereotyped spatial distribution of brain disconnections. While the former has granted us the possibility to map 590 functions on the white matter of the whole brain, the latter compels a revision of the taxonomy of brain functions. Overall, our freely available Atlas of White Matter Function will enable improved clinical-neuroanatomical predictions for brain lesion studies and provide a platform for explorations in the domain of cognition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.