ArticleNature communications2020
Identification of 31 loci for mammographic density phenotypes and their associations with breast cancer risk.
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Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34citing papers in PubMed
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Who cites it
34 citing papers in PubMed.
- Integrating breast cancer polygenic risk scores at scale in the WISDOM Study: a national randomized personalized screening trial.Genome medicine · 2025Trial
- Early-adulthood body mass index, mammographic density and post-menopausal breast cancer risk: a mediation analysis.British journal of cancer · 2026Article
- Polygenic Risk Scores for Breast Cancer Among African American Women With High Risk.JAMA network open · 2026Article
- Compact breast parenchyma: imaging and transcriptomic correlates.Journal of translational medicine · 2026Article
- Interactions between genetic and epidemiological factors influencing mammographic density.American journal of epidemiology · 2026Article
- Evaluating mammographic density polygenic risk score for contralateral breast cancer risk prediction.Scientific reports · 2026Article
- Association of Breast Density with Breast Cancer Risk and Stage at Diagnosis: A Korean Nationwide Cohort Study.Cancers · 2025Article
- Cell-type aware transcriptome-wide association study of mammographic density phenotypes.medRxiv : the preprint server for health sciences · 2025Article
- Genome-wide association study of Asian women identifies putative mammographic density-associated loci.Breast cancer research : BCR · 2025Article
- Scalable Deep Learning of Histology Images Reveals Genetic and Phenotypic Determinants of Adipocyte Hypertrophy.medRxiv : the preprint server for health sciences · 2025Article
- Article
- Causal Effects of Breast Cancer Risk Factors across Hormone Receptor Breast Cancer Subtypes: A Two-Sample Mendelian Randomization Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Article
- Human cytomegalovirus infection coopts chromatin organization to diminish TEAD1 transcription factor activity.bioRxiv : the preprint server for biology · 2025Article
- Identifying breast cancer risk factors and evaluating biennial mammography screening efficacy using big data analysis in Taiwan.Scientific reports · 2025Article
- Case Report: Pathological complete response yet early brain relapse in HER2-positive breast cancer: a case-based review.Frontiers in immunology · 2025Review
- [Examination of breast density in breast cancer discordant twin pairs].Magyar onkologia · 2024Article
- Genetic landscape of interval and screen detected breast cancer.NPJ precision oncology · 2024Article
- Mammographic density mediates the protective effect of early-life body size on breast cancer risk.Nature communications · 2024Article
- Association between Family History of Breast Cancer and Breast Density in Saudi Premenopausal Women Participating in Mammography Screening.Clinics and practice · 2024Article
- The mediating role of mammographic density in the protective effect of early-life adiposity on breast cancer risk: a multivariable Mendelian randomization study.medRxiv : the preprint server for health sciences · 2023Article
Corrections and comments
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Authors and funding
20 authors.
Weiva SiehDepartment of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA. weiva.sieh@mssm.edu.ORCID http://orcid.org/0000-0003-0085-1190
Joseph H RothsteinDepartment of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Robert J KleinDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0003-3539-5391
Stacey E AlexeeffDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Lori C SakodaDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.ORCID http://orcid.org/0000-0002-0900-5735
Eric JorgensonDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.ORCID http://orcid.org/0000-0002-5829-8191
Russell B McBrideDepartment of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-3890-529X
Rebecca E GraffDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-0316-8303
Valerie McGuireDepartment of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA, USA.
Ninah AchacosoDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Luana ActonDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Rhea Y LiangDepartment of Radiology, Stanford University School of Medicine, Stanford, CA, USA.
Jafi A LipsonDepartment of Radiology, Stanford University School of Medicine, Stanford, CA, USA.
Daniel L RubinDepartment of Radiology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-5057-4369
Martin J YaffeDepartments of Medical Biophysics and Medical Imaging, University of Toronto, Toronto, ON, Canada.
Douglas F EastonCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care and Department of Oncology, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-2444-3247
Catherine SchaeferDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.ORCID http://orcid.org/0000-0003-2644-055X
Neil RischDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Alice S WhittemoreDepartment of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA, USA.
Laurel A HabelDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Funding
A Resource for Genetic Epidemiology Research in Adult Health and AgingRC2AG036607 · NIA · KAISER FOUNDATION RESEARCH INSTITUTE · PI RISCH, NEIL J., SCHAEFER, CATHERINE ANN · 2009 to 2010
$24.8MEpidemiologic StudiesU19CA148065 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI AHSAN, HABIBUL, BRUGGE, JOAN SIEFERT · 2010 to 2014
$10.6MGenome-Wide Association Study of Mammographic DensityR01CA166827 · NCI · STANFORD UNIVERSITY · PI HABEL, LAUREL A, SIEH, WEIVA · 2012 to 2016
$2.3MMammographic Density & Prognosis among Breast Cancer Intrinsic SubtypesR01CA168893 · NCI · KAISER FOUNDATION RESEARCH INSTITUTE · PI HABEL, LAUREL A · 2012 to 2015
$2.1MBig Omics Data Engine 2 SupercomputerS10OD026880 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2019 to 2019
$2.0MGenomic and Transcriptomic Analysis of Mammographic DensityR01CA237541 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI HABEL, LAUREL A, SIEH, WEIVA · 2020 to 2023
$2.0MGenetic Epidemiology of Ovarian and Prostate CancerK07CA143047 · NCI · STANFORD UNIVERSITY · PI SIEH, WEIVA · 2010 to 2014
$867kCancer Research UK 17523Cancer Research UK C1287/A10118Cancer Research UK C1287/A10710Cancer Research UK C1287/A16563NCI NIH HHS K07 CA143047NCI NIH HHS R01 CA166827NCI NIH HHS R01 CA168893NCI NIH HHS R01 CA237541NCI NIH HHS U19 CA148065NIA NIH HHS RC2 AG036607NIH HHS S10 OD026880
Abstract
Mammographic density (MD) phenotypes are strongly associated with breast cancer risk and highly heritable. In this GWAS meta-analysis of 24,192 women, we identify 31 MD loci at P < 5 × 10
Indexed as
Breast DensityGenetic Predisposition to DiseaseAdultAgedAged, 80 and overBreast NeoplasmsFemaleGenome-Wide Association StudyHumansMammographyMendelian Randomization AnalysisMiddle AgedPolymorphism, Single Nucleotide
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