Evidence map›Paper›PMID 33037212›Full record

ArticleNature communications2020

Development and evaluation of an artificial intelligence system for COVID-19 diagnosis.

Cheng Jin, Weixiang Chen, Yukun Cao, Zhanwei Xu, Zimeng Tan, Xin Zhang, Lei Deng, Chuansheng Zheng, Jie Zhou, Heshui Shi and 1 more

Abstract readEvaluation StudyMulticenter Study
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 236 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
236citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

236 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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  9. Performance of AI Approaches for COVID-19 Diagnosis Using Chest CT Scans: The Impact of Architecture and Dataset.RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin · 2026
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176 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Cheng Jin *Department of Automation, Beijing National Research Center for Information Science and Technology, Tsinghua University, Beijing, China.
Weixiang Chen *Department of Automation, Beijing National Research Center for Information Science and Technology, Tsinghua University, Beijing, China.
Yukun Cao *Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.ORCID http://orcid.org/0000-0002-8391-841X
Zhanwei XuDepartment of Automation, Beijing National Research Center for Information Science and Technology, Tsinghua University, Beijing, China.
Zimeng TanDepartment of Automation, Beijing National Research Center for Information Science and Technology, Tsinghua University, Beijing, China.
Xin ZhangDepartment of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Lei DengDepartment of Automation, Beijing National Research Center for Information Science and Technology, Tsinghua University, Beijing, China.
Chuansheng ZhengDepartment of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.ORCID http://orcid.org/0000-0002-2435-1417
Jie ZhouDepartment of Automation, Beijing National Research Center for Information Science and Technology, Tsinghua University, Beijing, China.
Heshui ShiDepartment of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. heshuishi@hust.edu.cn.ORCID http://orcid.org/0000-0002-0877-3054
Jianjiang FengDepartment of Automation, Beijing National Research Center for Information Science and Technology, Tsinghua University, Beijing, China. jfeng@tsinghua.edu.cn.ORCID http://orcid.org/0000-0002-5940-0063

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Early detection of COVID-19 based on chest CT enables timely treatment of patients and helps control the spread of the disease. We proposed an artificial intelligence (AI) system for rapid COVID-19 detection and performed extensive statistical analysis of CTs of COVID-19 based on the AI system. We developed and evaluated our system on a large dataset with more than 10 thousand CT volumes from COVID-19, influenza-A/B, non-viral community acquired pneumonia (CAP) and non-pneumonia subjects. In such a difficult multi-class diagnosis task, our deep convolutional neural network-based system is able to achieve an area under the receiver operating characteristic curve (AUC) of 97.81% for multi-way classification on test cohort of 3,199 scans, AUC of 92.99% and 93.25% on two publicly available datasets, CC-CCII and MosMedData respectively. In a reader study involving five radiologists, the AI system outperforms all of radiologists in more challenging tasks at a speed of two orders of magnitude above them. Diagnosis performance of chest x-ray (CXR) is compared to that of CT. Detailed interpretation of deep network is also performed to relate system outputs with CT presentations. The code is available at https://github.com/ChenWWWeixiang/diagnosis_covid19 .

Indexed as

Artificial IntelligenceAdultAgedAged, 80 and overBetacoronavirusCoronavirus InfectionsCOVID-19Deep LearningDiagnosis, DifferentialFemaleHumansMaleMiddle AgedPandemicsPneumoniaPneumonia, Viral

Identifiers

PMID33037212
PMCPMC7547659

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.