Evidence map›Paper›PMID 33037202›Full record

ArticleNature communications2020

Adaptive thermogenesis enhances the life-threatening response to heat in mice with an Ryr1 mutation.

Hui J Wang, Chang Seok Lee, Rachel Sue Zhen Yee, Linda Groom, Inbar Friedman, Lyle Babcock, Dimitra K Georgiou, Jin Hong, Amy D Hanna, Joseph Recio and 13 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Gabpα-Pparγ Complex Determines Glycolytic Capacity and Lactic Acid Homeostasis in Brown Fat.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Phosphorylation of RYR1 at SerScience signaling · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Rna MAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
  11. Article
  12. Article
  13. Review
  14. Adipose Tissue Remodeling in Pathophysiology.Annual review of pathology · 2023
    Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Pathological mechanisms of vacuolar aggregate myopathy arising from a Casq1 mutation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 4 institutions in 3 countries.

Hui J Wang *Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0003-2654-0243
Chang Seok Lee *Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA.
Rachel Sue Zhen YeeDepartment of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA.
Linda GroomDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY, USA.
Inbar FriedmanDepartment of Anesthesiology, University of Toronto, Toronto, ON, Canada.
Lyle BabcockDepartment of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA.
Dimitra K GeorgiouDepartment of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0001-8786-2495
Jin HongDepartment of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA.
Amy D HannaDepartment of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA.
Joseph RecioDepartment of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA.
Jong Min ChoiAdvance Technology Core, Mass Spectrometry Proteomics Core, Baylor College of Medicine, Houston, TX, USA.
Ting ChangDepartment of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA.
Nadia H AghaDepartment of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA.
Jonathan RomeroDepartment of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA.
Poonam SarkarDepartment of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Nicol VoermansDepartment of Neurology, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Centre, Nijmegen, Netherlands.
M Waleed GaberDepartment of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA.
Sung Yun JungAdvance Technology Core, Mass Spectrometry Proteomics Core, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0003-1521-7977
Matthew L BakerAdvance Technology Core, Mass Spectrometry Proteomics Core, Baylor College of Medicine, Houston, TX, USA.
Robia G PautlerDepartment of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA.
Robert T DirksenDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY, USA.
Sheila RiaziDepartment of Anesthesiology, University of Toronto, Toronto, ON, Canada.
Susan L HamiltonDepartment of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA. susanh@bcm.edu.ORCID http://orcid.org/0000-0003-0241-9369
Baylor College of Medicine · USUniversity of Rochester Medical Center · USUniversity of Toronto · CARadboud University Nijmegen · NL

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Michael M Ittmann · 2007 to 2026
$73.9M
Basis of Muscle Dysfunction in Malignant Hyperthermia & Central Core DiseaseR01AR053349 · NIAMS · BAYLOR COLLEGE OF MEDICINE · PI DIRKSEN, ROBERT T, HAMILTON, SUSAN L · 2006 to 2020
$8.0M
Molecular Physiology of the Cardiovascular SystemT32HL007676 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI HAMILTON, SUSAN L · 1989 to 2020
$7.9M
Mechanisms of couplon-linked skeletal muscle myopathiesR01AR072602 · NIAMS · BAYLOR COLLEGE OF MEDICINE · PI HAMILTON, SUSAN L, HORRIGAN, FRANK T · 2018 to 2022
$3.3M
Redefining the Role of FKBP12 in Skeletal MuscleR01AR072475 · NIAMS · BAYLOR COLLEGE OF MEDICINE · PI DIRKSEN, ROBERT T, HAMILTON, SUSAN L · 2018 to 2022
$2.9M
The HH: A Large Cohort of Patients with Congenital Myopathies of Uncertain EtiologyR01AR071381 · NIAMS · RUSH UNIVERSITY MEDICAL CENTER · PI FILL, MICHAEL, RIAZI, SHEILA · 2017 to 2021
$2.7M
Howard Hughes Medical InstituteNCI NIH HHS P30 CA125123NHLBI NIH HHS T32 HL007676NIAMS NIH HHS R01 AR053349NIAMS NIH HHS R01 AR071381NIAMS NIH HHS R01 AR072602
6 · The paper itself

Abstract

Mutations in the skeletal muscle Ca

Indexed as

MutationAdipose Tissue, BrownAdolescentAdultAnimalsChildChild, PreschoolFemaleHeat-Shock ResponseHumansInfantLactatesMaleMalignant HyperthermiaMice, Inbred C57BLMice, KnockoutLactatesryanodine receptor 1, mouseRyanodine Receptor Calcium Release ChannelRYR1 protein, humanUcp1 protein, mouseUncoupling Protein 1

Identifiers

PMID33037202
PMCPMC7547078
OpenAlexW3092410821

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.