Evidence map›Paper›PMID 33037140›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2020

Role of Tunneling Nanotube-like Structures during the Early Events of HIV Infection: Novel Features of Tissue Compartmentalization and Mechanism of HIV Spread.

George Okafo, Silvana Valdebenito, Maribel Donoso, Ross Luu, David Ajasin, Brendan Prideaux, Santhi Gorantla, Eliseo A Eugenin

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 18 citations in OpenAlex.

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  6. A role for tunneling nanotubes in virus spread.Frontiers in microbiology · 2024
    Review
  7. Mechanisms of Intracellular Communication in Cancer and Pathogen Spreading.Results and problems in cell differentiation · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

George OkafoGO Pharma Consulting Ltd., Welwyn AL6 0QT, United Kingdom.
Silvana ValdebenitoDepartment of Neuroscience, Cell Biology and Anatomy, University of Texas Medical Branch, Galveston, TX 77555; and.
Maribel DonosoDepartment of Neuroscience, Cell Biology and Anatomy, University of Texas Medical Branch, Galveston, TX 77555; and.ORCID 0000-0003-1377-9466
Ross LuuDepartment of Neuroscience, Cell Biology and Anatomy, University of Texas Medical Branch, Galveston, TX 77555; and.ORCID 0000-0001-6364-0783
David AjasinDepartment of Neuroscience, Cell Biology and Anatomy, University of Texas Medical Branch, Galveston, TX 77555; and.ORCID 0000-0003-1061-1860
Brendan PrideauxDepartment of Neuroscience, Cell Biology and Anatomy, University of Texas Medical Branch, Galveston, TX 77555; and.
Santhi GorantlaDepartment of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198.
Eliseo A EugeninDepartment of Neuroscience, Cell Biology and Anatomy, University of Texas Medical Branch, Galveston, TX 77555; and eleugeni@UTMB.edu.ORCID 0000-0002-2925-4720
The University of Texas Medical Branch at Galveston · USNebraska Medical Center · USWelch Foundation · US

Funding

Astrocyte connexin43 containing channels amplify CNS dysfunction in NeuroAIDSR01MH096625 · NIMH · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI EUGENIN, ELISEO A · 2012 to 2020
$4.5M
Role of pannexin-1 hemichannels in NeuroAIDSR01NS105584 · NINDS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI EUGENIN, ELISEO A · 2017 to 2021
$3.2M
Metabolic strategies to eliminate CNS Myeloid Viral ReservoirsR01MH128082 · NIMH · UNIVERSITY OF TEXAS MED BR GALVESTON · PI EUGENIN, ELISEO A · 2021 to 2025
$3.1M
NIMH NIH HHS R01 MH096625NIMH NIH HHS R01 MH128082NINDS NIH HHS R01 NS105584
6 · The paper itself

Abstract

HIV has become a chronic disease despite the effective use of antiretroviral therapy (ART). However, the mechanisms of tissue colonization, viral evolution, generation of viral reservoirs, and compartmentalization are still a matter of debate due to the challenges involved in examining early events of infection at the cellular and molecular level. Thus, there is still an urgent need to explore these areas to develop effective HIV cure strategies. In this study, we describe the early events of tissue colonization and compartmentalization as well as the role of tunneling nanotube-like structures during viral spread in the presence and absence of effective antiretroviral treatment. To examine these mechanisms, NOD/SCID IL-2 RG

Indexed as

AmidesAnimalsAnti-Retroviral AgentsCD4-Positive T-LymphocytesDisease Models, AnimalHematopoietic Stem Cell TransplantationHIV-1HIV InfectionsHumansInterleukin Receptor Common gamma SubunitMiceMice, KnockoutQuaternary Ammonium CompoundsTransplantation ChimeraViral LoadVirus IntegrationAmidesAnti-Retroviral AgentsIl2rg protein, mouseInterleukin Receptor Common gamma SubunitQuaternary Ammonium CompoundsTAK 779

Identifiers

PMID33037140
PMCPMC8034560
OpenAlexW3091965339

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.