Evidence map›Paper›PMID 33037073›Full record

ArticleThe Journal of biological chemistry2020

Leptin modulates pancreatic β-cell membrane potential through Src kinase-mediated phosphorylation of NMDA receptors.

Veronica A Cochrane, Yi Wu, Zhongying Yang, Assmaa ElSheikh, Jeremy Dunford, Paul Kievit, Dale A Fortin, Show-Ling Shyng

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 22 citations in OpenAlex.

  1. Glaucine suppresses IL-16/CD4 to alleviate neuropathic pain via spinal p56Naunyn-Schmiedeberg's archives of pharmacology · 2026
    Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Posttranslational modifications in diabetes: Mechanisms and functions.Reviews in endocrine & metabolic disorders · 2022
    Review
  8. Subcellular trafficking and endocytic recycling of KAmerican journal of physiology. Cell physiology · 2022
    Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Veronica A CochraneDepartment of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, Oregon, USA.
Yi WuDepartment of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, Oregon, USA.
Zhongying YangDepartment of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, Oregon, USA.
Assmaa ElSheikhDepartment of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, Oregon, USA; Department of Medical Biochemistry, Tanta University, Tanta, Egypt.
Jeremy DunfordDepartment of Integrated Physiology and Neuroscience, College of Arts and Sciences, Washington State University, Vancouver, Washington, USA.
Paul KievitDivision of Cardiometabolic Health, Oregon National Primate Research Center, Beaverton, Oregon, USA.
Dale A FortinDepartment of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, Oregon, USA; Department of Integrated Physiology and Neuroscience, College of Arts and Sciences, Washington State University, Vancouver, Washington, USA. Electronic address: dale.fortin@wsu.edu.
Show-Ling ShyngDepartment of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, Oregon, USA. Electronic address: shyngs@ohsu.edu.
Oregon Health & Science University · USWashington State University Vancouver · USOregon National Primate Research Center · US

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
KATP channels and insulin secretionR01DK057699 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI SHYNG, SHOW-LING · 2001 to 2019
$6.1M
NIDDK NIH HHS R01 DK057699NIH HHS P51 OD011092
6 · The paper itself

Abstract

The adipocyte-derived hormone leptin increases trafficking of K

Indexed as

Membrane PotentialsAnimalsCell LineDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2HumansInsulin-Secreting CellsLeptinMiceMice, Mutant StrainsMutationObesityPhosphorylationReceptors, N-Methyl-D-Aspartatesrc-Family KinasesLEP protein, humanLeptinNR2B NMDA receptorReceptors, N-Methyl-D-Aspartatesrc-Family Kinasesbeta cell (B-cell)GluN2Aglutamate receptorKATP channelphosphorylationSrcSrc kinasetype 2 diabetesβ-cells

Identifiers

PMID33037073
PMCPMC7863909
OpenAlexW3092551670

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.