Evidence map›Paper›PMID 33037049›Full record

ArticleGenetics2020

Humanized

Maxim Balasov, Katarina Akhmetova, Igor Chesnokov

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Maxim BalasovDepartment of Biochemistry and Molecular Genetics, School of Medicine, University of Alabama at Birmingham, Alabama 35294.
Katarina AkhmetovaDepartment of Biochemistry and Molecular Genetics, School of Medicine, University of Alabama at Birmingham, Alabama 35294.
Igor ChesnokovDepartment of Biochemistry and Molecular Genetics, School of Medicine, University of Alabama at Birmingham, Alabama 35294 ichesnokov@uab.edu.ORCID 0000-0002-6659-2913
University of Alabama at Birmingham · US

Funding

The role of Orc6 in DNA replication and cytokinesis.R01GM121449 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CHESNOKOV, IGOR N · 2017 to 2023
$2.6M
NIGMS NIH HHS R01 GM121449
6 · The paper itself

Abstract

Meier-Gorlin syndrome (MGS) is a rare, autosomal recessive disorder characterized by microtia, primordial dwarfism, small ears, and skeletal abnormalities. Patients with MGS often carry mutations in genes encoding the subunits of the Origin Recognition Complex (ORC), components of the prereplicative complex and replication machinery. Orc6 is an important component of ORC and has functions in both DNA replication and cytokinesis. A mutation in the conserved C-terminal motif of Orc6 associated with MGS impedes the interaction of Orc6 with core ORC. Recently, a new mutation in Orc6 was also identified; however, it is localized in the N-terminal domain of the protein. To study the functions of Orc6, we used the human gene to rescue the

Indexed as

AnimalsBinding SitesCongenital MicrotiaConserved SequenceDrosophila melanogasterGrowth DisordersHumansMicrognathismMutationOrigin Recognition ComplexPatellaProtein BindingTransgenesORC6 protein, humanOrigin Recognition ComplexDNA replicationDrosophilaMeier–Gorlin syndromeORC

Identifiers

PMID33037049
PMCPMC7768257
OpenAlexW3092236802

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.