ArticleBiology open2020
Amyloid-beta peptide and phosphorylated tau in the frontopolar cerebral cortex and in the cerebellum of toothed whales: aging versus hypoxia.
Article in Biology open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Neurodegenerative Diseases: What Can Be Learned from Toothed Whales?Neuroscience bulletin · 2025Pooled it
- Astrocyte properties in cetacean cortices.Physiological reports · 2025Article
- Morphology of the glymphatic and meningeal lymphatic structures of the bottlenose dolphin.Scientific reports · 2025Article
- "Of Marine Mammal Neuroscience and Men": Needs and Perspectives in Marine Mammal Neuroscience.The Journal of comparative neurology · 2025Review
- Aging-Associated Amyloid-β Plaques and Neuroinflammation in Bottlenose Dolphins (International journal of molecular sciences · 2025Article
- Meningeal Lymphatic and Glymphatic Structures in a Pelagic Delphinid (Animals : an open access journal from MDPI · 2025Article
- Spontaneous mammalian models for Alzheimer's disease and dementia.Brain communications · 2025Review
- Central Nervous System Disorders of Marine Mammals: Models for Human Disease?Pathogens (Basel, Switzerland) · 2024Review
- Alzheimer's Disease Neuropathological Change in Aged Non-Primate Mammals.International journal of molecular sciences · 2024Review
- Article
- Editorial: New insights in the neuroanatomy and neuropathology of marine mammals.Frontiers in neuroanatomy · 2024Article
- Alzheimer's disease-like neuropathology in three species of oceanic dolphin.The European journal of neuroscience · 2023Article
- Multimodal Assessment of Bottlenose Dolphin Auditory Nuclei Using 7-Tesla MRI, Immunohistochemistry and Stereology.Veterinary sciences · 2022Article
- Toothed Whales Have Black Neurons in the Blue Spot.Veterinary sciences · 2022Article
- Methodology and Neuromarkers for Cetaceans' Brains.Veterinary sciences · 2022Article
- Article
- Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypoxia could be a possible risk factor for neurodegenerative alterations in cetaceans' brain. Among toothed whales, the beaked whales are particularly cryptic and routinely dive deeper than 1000 m for about 1 h in order to hunt squids and fishes. Samples of frontal cerebral and cerebellar cortex were collected from nine animals, representing six different species of the suborder Odontoceti. Immunohistochemical analysis employed anti-β-amyloid (Aβ) and anti-neurofibrillary tangle (NFT) antibodies. Six of nine (67%) animals showed positive immunolabeling for Aβ and/or NFT. The most striking findings were intranuclear Aβ immunopositivity in cerebral cortical neurons and NFT immunopositivity in cerebellar Purkinje neurons with granulovacuolar degeneration. Aβ plaques were also observed in one elderly animal. Herein, we present immunohistopathological findings classic of Alzheimer's and other neurodegenerative diseases in humans. Our findings could be linked to hypoxic phenomena, as they were more extensive in beaked whales. Despite their adaptations, cetaceans could be vulnerable to sustained and repetitive brain hypoxia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.