ArticleScience advances2020
Cortical and striatal circuits together encode transitions in natural behavior.
Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- A basolateral amygdala to dorsolateral striatum projection modulates stimulus-evoked motor behavior.Neuron · 2026Article
- Behavior Decoding Delineates Seizure Microfeatures and Associated Sudden Death Risks in Mouse Models of Epilepsy.Annals of neurology · 2026Article
- Control of striatal circuit development by the chromatin regulatorScience advances · 2025Article
- The neurobiology of parenting and infant-evoked aggression.Physiological reviews · 2025Review
- Striatal ensemble activity in an innate naturalistic behavior.bioRxiv : the preprint server for biology · 2023Article
- Manipulation-specific cortical activity as mice handle food.Current biology : CB · 2022Article
- Midbrain dopamine neurons arbiter OCD-like behavior.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Cortico-striatal circuits for bilaterally coordinated movements.Science advances · 2022Article
- The basal ganglia control the detailed kinematics of learned motor skills.Nature neuroscience · 2021Article
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Authors and funding
5 authors.
Funding
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Abstract
In natural behavior, we fluidly change from one type of activity to another in a sequence of motor actions. Corticostriatal circuits are thought to have a particularly important role in the construction of action sequences, but neuronal coding of a sequential behavior consisting of different motor programs has not been investigated at the circuit level in corticostriatal networks, making the exact nature of this involvement elusive. Here, we show, by analyzing spontaneous self-grooming in rats, that neuronal modulation in motor cortex and dorsal striatum is strongly related to transitions between behaviors. Our data suggest that longer action sequences in rodent grooming behavior emerge from stepwise control of individual behavioral transitions, where future actions are encoded differently depending on current motor state. This state-dependent motor coding was found to differentiate between rare behavioral transitions and as opposed to more habitual sequencing of actions.
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