ReviewMolecules (Basel, Switzerland)2020
Natural Compound-derived Cytochrome bc1 Complex Inhibitors as Antifungal Agents.
Review in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed.
- Histochemical and Semi-Quantitative Evidence of Dimoxystrobin-Induced Liver Extracellular Matrix Remodelling in Adult Zebrafish.Journal of xenobiotics · 2026Article
- Pyraclostrobin impairs metabolic activity and phosphorus uptake of the extraradical mycelium of Rhizophagus intraradices more severely than iprodione.Mycorrhiza · 2026Article
- Potential of Boronic Acid Derivatization and Activity in Agrochemical Discovery.Molecules (Basel, Switzerland) · 2025Review
- Insight into the Structure of Antifungal Cyrmenins: Conformational Studies of Unique Dehydroamino Acid, O-Methyldehydroserine.International journal of molecular sciences · 2025Article
- Lansoprazole interferes with fungal respiration and acts synergistically with amphotericin B against multidrug-resistantEmerging microbes & infections · 2024Article
- Network analysis of toxic endpoints of fungicides in zebrafish.Toxicology research · 2024Review
- Strobilurin X acts as an anticancer drug by inhibiting protein synthesis and suppressing mitochondrial respiratory chain activity.Discover oncology · 2024Article
- Innovations in Antifungal Drug Discovery among Cell Envelope Synthesis Enzymes through Structural Insights.Journal of fungi (Basel, Switzerland) · 2024Review
- Synergistic Effects of Oligochitosan and Pyraclostrobin in Controlling Leaf Spot Disease inAntibiotics (Basel, Switzerland) · 2024Article
- Natural Polyketides Act as Promising Antifungal Agents.Biomolecules · 2023Review
- Do mitochondria use efflux pumps to protect their ribosomes from antibiotics?Microbiology (Reading, England) · 2023Article
- In silico investigation of cytochrome bc1 molecular inhibition mechanism against Trypanosoma cruzi.PLoS neglected tropical diseases · 2023Article
- Chitosan as an Adjuvant to Enhance the Control Efficacy of Low-Dosage Pyraclostrobin against Powdery Mildew ofBiomolecules · 2022Article
- Targeting the alternative oxidase (AOX) for human health and food security, a pharmaceutical and agrochemical target or a rescue mechanism?The Biochemical journal · 2022Review
- Design, synthesis and fungicidal activity of 3,4-dichloroisothiazolocoumarin-containing strobilurins.Molecular diversity · 2022Article
- Search for Novel Lead Inhibitors of Yeast Cytochrome bc1, from Drugbank and COCONUT.Molecules (Basel, Switzerland) · 2021Article
- Structural Investigation and Molecular Modeling Studies of Strobilurin-Based Fungicides Active against the Rice Blast PathogenInternational journal of molecular sciences · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The high incidence of fungal pathogens has become a global issue for crop protection. A promising strategy to control fungal plant infections is based on the use of nature-inspired compounds. The cytochrome bc1 complex is an essential component of the cellular respiratory chain and is one of the most important fungicidal targets. Natural products have played a crucial role in the discovery of cytochrome bc1 inhibitors, as proven by the development of strobilurins, one of the most important classes of crop-protection agents, over the past two decades. In this review, we summarize advances in the exploration of natural product scaffolds for the design and development of new bc1 complex inhibitors. Particular emphasis is given to molecular modeling-based approaches and structure-activity relationship (SAR) studies performed to improve the stability and increase the potency of natural precursors. The collected results highlight the versatility of natural compounds and provide an insight into the potential development of nature-inspired derivatives as antifungal agents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.