Evidence map›Paper›PMID 33036493›Full record

ArticleInternational journal of molecular sciences2020

Antioxidant Amelioration of Riboflavin Transporter Deficiency in Motoneurons Derived from Patient-Specific Induced Pluripotent Stem Cells.

Chiara Marioli, Valentina Magliocca, Stefania Petrini, Alessia Niceforo, Rossella Borghi, Sara Petrillo, Piergiorgio La Rosa, Fiorella Colasuonno, Tiziana Persichini, Fiorella Piemonte and 5 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Riboflavin transporter deficiency:Frontiers in cellular neuroscience · 2025
    Article
  4. Genes & diseases · 2024
    Article
  5. Article
  6. Article
  7. Review
  8. hiPSC-Derived Cells as Models for Drug Discovery.International journal of molecular sciences · 2021
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Chiara MarioliGenetics and Rare Diseases Research Division, IRCCS Ospedale Pediatrico Bambino Gesù, 00146 Rome, Italy.
Valentina MaglioccaDepartment of Science, University Roma Tre, 00146 Rome, Italy.
Stefania PetriniConfocal Microscopy Core Facility, Research Laboratories, IRCCS Ospedale Pediatrico Bambino Gesù, 00146 Rome, Italy.ORCID 0000-0002-3249-0003
Alessia NiceforoUnit of Neuromuscular and Neurodegenerative Diseases, Laboratory of Molecular Medicine, Department of Neuroscience, IRCCS Ospedale Pediatrico Bambino Gesù, 00146 Rome, Italy.
Rossella BorghiUnit of Neuromuscular and Neurodegenerative Diseases, Laboratory of Molecular Medicine, Department of Neuroscience, IRCCS Ospedale Pediatrico Bambino Gesù, 00146 Rome, Italy.
Sara PetrilloUnit of Neuromuscular and Neurodegenerative Diseases, Laboratory of Molecular Medicine, Department of Neuroscience, IRCCS Ospedale Pediatrico Bambino Gesù, 00146 Rome, Italy.
Piergiorgio La RosaDepartment of Psychology, Division of Neuroscience, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-9723-2363
Fiorella ColasuonnoGenetics and Rare Diseases Research Division, IRCCS Ospedale Pediatrico Bambino Gesù, 00146 Rome, Italy.ORCID 0000-0002-4894-5084
Tiziana PersichiniDepartment of Science, University Roma Tre, 00146 Rome, Italy.
Fiorella PiemonteUnit of Neuromuscular and Neurodegenerative Diseases, Laboratory of Molecular Medicine, Department of Neuroscience, IRCCS Ospedale Pediatrico Bambino Gesù, 00146 Rome, Italy.ORCID 0000-0003-1825-9347
Keith MasseyScience Director, Cure RTD Foundation, 6228 Northaven Rd., Dallas, TX 75230, USA.
Marco TartagliaGenetics and Rare Diseases Research Division, IRCCS Ospedale Pediatrico Bambino Gesù, 00146 Rome, Italy.
Sandra MorenoDepartment of Science, LIME, University Roma Tre, 00146 Rome, Italy.ORCID 0000-0002-1079-3222
Enrico BertiniUnit of Neuromuscular and Neurodegenerative Diseases, Laboratory of Molecular Medicine, Department of Neuroscience, IRCCS Ospedale Pediatrico Bambino Gesù, 00146 Rome, Italy.ORCID 0000-0001-9276-4590
Claudia CompagnucciGenetics and Rare Diseases Research Division, IRCCS Ospedale Pediatrico Bambino Gesù, 00146 Rome, Italy.ORCID 0000-0003-0877-6172
Bambino Gesù Children's Hospital · ITRoma Tre University · ITCOPD Foundation · USSapienza University of Rome · IT

Funding

Cure RTD Foundation ResearchFondazione Bambino Gesù RicercaMinistero della Salute Cinque per MilleMinistero della Salute Ricerca corrente
6 · The paper itself

Abstract

Mitochondrial dysfunction is a key element in the pathogenesis of neurodegenerative disorders, such as riboflavin transporter deficiency (RTD). This is a rare, childhood-onset disease characterized by motoneuron degeneration and caused by mutations in

Indexed as

AnimalsAntioxidantsBiomarkersBulbar Palsy, ProgressiveCalciumCell DifferentiationDisease Models, AnimalHearing Loss, SensorineuralHumansInduced Pluripotent Stem CellsLipid MetabolismMembrane Transport ProteinsMiceMice, KnockoutMotor NeuronsOxidation-ReductionAntioxidantsBiomarkersCalciumMembrane Transport ProteinsRiboflavinantioxidantsiPSCsmitochondriamotoneuronsneurodegenerative diseaseoxidative stressriboflavin transportersRTD syndrome

Identifiers

PMID33036493
PMCPMC7582490
OpenAlexW3092184626

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.