Evidence map›Paper›PMID 33036467›Full record

ReviewBiomolecules2020

Harnessing Mechanosensation in Next Generation Cardiovascular Tissue Engineering.

Gloria Garoffolo, Silvia Ferrari, Stefano Rizzi, Marianna Barbuto, Giacomo Bernava, Maurizio Pesce

Abstract readReview
In one paragraph

Review in Biomolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Unveiling the intricacies of cardiac valve pathophysiology.Frontiers in cardiovascular medicine · 2025
    Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. [Research Progress in Mechanotransduction Process of Mechanical-Stress-Induced Autophagy].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2021
    Review
  9. Review
  10. Article
  11. Vascular dysfunction and pathology: focus on mechanical forces.Vascular biology (Bristol, England) · 2021
    Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gloria GaroffoloUnità di Ingegneria Tissutale Cardiovascolare, Centro Cardiologico Monzino, IRCCS, 20138 Milan, Italy.
Silvia FerrariUnità di Ingegneria Tissutale Cardiovascolare, Centro Cardiologico Monzino, IRCCS, 20138 Milan, Italy.
Stefano RizziUnità di Ingegneria Tissutale Cardiovascolare, Centro Cardiologico Monzino, IRCCS, 20138 Milan, Italy.ORCID 0000-0003-1282-3322
Marianna BarbutoUnità di Ingegneria Tissutale Cardiovascolare, Centro Cardiologico Monzino, IRCCS, 20138 Milan, Italy.
Giacomo BernavaUnità di Ingegneria Tissutale Cardiovascolare, Centro Cardiologico Monzino, IRCCS, 20138 Milan, Italy.
Maurizio PesceUnità di Ingegneria Tissutale Cardiovascolare, Centro Cardiologico Monzino, IRCCS, 20138 Milan, Italy.ORCID 0000-0002-3097-8961

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ability of the cells to sense mechanical cues is an integral component of "social" cell behavior inside tissues with a complex architecture. Through "mechanosensation" cells are in fact able to decrypt motion, geometries and physical information of surrounding cells and extracellular matrices by activating intracellular pathways converging onto gene expression circuitries controlling cell and tissue homeostasis. Additionally, only recently cell mechanosensation has been integrated systematically as a crucial element in tissue pathophysiology. In the present review, we highlight some of the current efforts to assess the relevance of mechanical sensing into pathology modeling and manufacturing criteria for a next generation of cardiovascular tissue implants.

Indexed as

Mechanotransduction, CellularTissue EngineeringAnimalsCardiovascular SystemExtracellular MatrixHumanscardiac regenerationmechanosensingtissue engineering

Identifiers

PMID33036467
PMCPMC7599461

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.