SynthesisCells2020
Effectiveness of Autologous Platelet Concentrates in Management of Young Immature Necrotic Permanent Teeth-A Systematic Review and Meta-Analysis.
Synthesis in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Regenerative Endodontic Procedures in Teeth with Root Resorption: A Systematic Review.European endodontic journal · 2023Pooled it
- Regenerative Endodontic Procedures: An Umbrella Review.International journal of environmental research and public health · 2021Pooled it
- Long-term outcomes of platelet-rich fibrin and blood clot scaffolds in regenerative endodontic treatment of traumatized immature maxillary incisors: An 80-month case report.Frontiers in dental medicine · 2026Article
- Evaluation of platelet concentrates in regenerative endodontics: a systematic review and meta-analysis.Restorative dentistry & endodontics · 2025Article
- Revascularizing ability of platelet-rich fibrin in permanent necrotic immature teeth: A systematic review and meta-analysis.Journal of conservative dentistry and endodontics · 2025Review
- Article
- Comparative Evaluation of Autologous Platelet Aggregates Versus Blood Clot On The Outcome Of Regenerative Endodontic Therapy: A Systematic Review and Meta-Analysis.Journal of clinical and experimental dentistry · 2025Review
- Comparative evaluation of platelet-rich plasma + β-tricalcium phosphate and platelet-rich fibrin + β-tricalcium phosphate for healing periapical lesions, using cone beam computed tomography - anMedicine and pharmacy reports · 2024Article
- Management Strategies for Immature Teeth with Pulp Necrosis: An Umbrella Review of Systematic Reviews.Iranian endodontic journal · 2024Review
- The efficacy of concentrated growth factor and platelet-rich fibrin as scaffolds in regenerative endodontic treatment applied to immature permanent teeth: a retrospective study.BMC oral health · 2023Article
- Mechanism of Pulp Regeneration Based on Concentrated Growth Factors Regulating Cell Differentiation.Bioengineering (Basel, Switzerland) · 2023Article
- Management of contralateral molar teeth with necrotic pulp and open apexes using platelet-rich plasma and vital pulp therapy.Clinical case reports · 2023Article
- Outcomes reporting in systematic reviews on revitalization: A scoping review for the development of a core outcome set.International endodontic journal · 2022Article
- Impact of being underweight on peri-operative and post-operative outcomes of total knee or hip arthroplasty: A meta-analysis.World journal of clinical cases · 2022Article
- A Bibliometric Analysis of Platelet-Rich Fibrin in Dentistry.International journal of environmental research and public health · 2022Article
- Clinical Outcome and Comparison of Regenerative and Apexification Intervention in Young Immature Necrotic Teeth-A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2022Review
- Article
- The Impact of Autologous Platelet Concentrates on the Periapical Tissues and Root Development of Replanted Teeth: A Systematic Review.Materials (Basel, Switzerland) · 2022Review
- Functional Dental Pulp Regeneration: Basic Research and Clinical Translation.International journal of molecular sciences · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The use of autologous platelet concentrates (APCs) in regenerative endodontic procedures is inconsistent and unclear. The aim of this meta-analysis was to evaluate the effectiveness of autologous platelet concentrates compared to traditional blood-clot regeneration for the management of young, immature, necrotic, permanent teeth. The digital databases MEDLINE, SCOPUS, CENTRAL, Web of Science, and EMBASE were searched to identify ten randomized clinical trials. The outcomes at postoperative follow-up, such as dentinal wall thickness (DWT), increase in root length (RL), calcific barrier formation (CB), apical closure (AC), vitality response (VR), and success rate (SR), were subjected to both qualitative synthesis and quantitative meta-analysis. The meta-analysis showed that APCs significantly improved apical closure (risk ratio (RR) = 1.17; 95% CI: 1.01, 1.37;
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.