Evidence map›Paper›PMID 33036404›Full record

ArticleNanomaterials (Basel, Switzerland)2020

Harnessing the Activation of Toll-Like Receptor 2/6 by Self-Assembled Cross-β Fibrils to Design Adjuvanted Nanovaccines.

Soultan Al-Halifa, Ximena Zottig, Margaryta Babych, Mélanie Côté-Cyr, Steve Bourgault, Denis Archambault

Open access · goldAbstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Moving Forward in Nano-Immune Interactions.Nanomaterials (Basel, Switzerland) · 2022
    Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Soultan Al-HalifaDepartment of Chemistry, Université du Québec à Montréal, Montreal, QC H2L 2C4, Canada.
Ximena ZottigDepartment of Chemistry, Université du Québec à Montréal, Montreal, QC H2L 2C4, Canada.
Margaryta BabychDepartment of Chemistry, Université du Québec à Montréal, Montreal, QC H2L 2C4, Canada.
Mélanie Côté-CyrDepartment of Chemistry, Université du Québec à Montréal, Montreal, QC H2L 2C4, Canada.
Steve BourgaultDepartment of Chemistry, Université du Québec à Montréal, Montreal, QC H2L 2C4, Canada.
Denis ArchambaultThe Swine and Poultry Infectious Diseases Research Centre, CRIPA, Saint-Hyacinthe, QC J2S 2M2, Canada.ORCID 0000-0001-9409-5140
Université du Québec à Montréal · CA

Funding

International Development Research Centre 108517Natural Sciences and Engineering Research Council of Canada RGPIN-2018-06209Natural Sciences and Engineering Research Council of Canada RGPN-2016-06532
6 · The paper itself

Abstract

Protein fibrils characterized with a cross-β-sheet quaternary structure have gained interest as nanomaterials in biomedicine, including in the design of subunit vaccines. Recent studies have shown that by conjugating an antigenic determinant to a self-assembling β-peptide, the resulting supramolecular assemblies act as an antigen delivery system that potentiates the epitope-specific immune response. In this study, we used a ten-mer self-assembling sequence (I

Indexed as

cross-β-sheetfibrilsimmune responseimmunizationinfluenza virusnanovaccineself-assembling peptidesself-assemblyTLR2/6toll-like receptor

Identifiers

PMID33036404
PMCPMC7600500
OpenAlexW3092202760

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.