Evidence map›Paper›PMID 33036360›Full record

ArticleNutrients2020

Longitudinal Changes in Resting Metabolic Rates with Aging Are Accelerated by Diseases.

Marta Zampino, Majd AlGhatrif, Pei-Lun Kuo, Eleanor Marie Simonsick, Luigi Ferrucci

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 3 pooled it
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 53 citations in OpenAlex.

  1. Pooled it
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  15. Metabolic equivalents intensity thresholds for physical activity classification in older adults.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2024
    Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Obesity and lifespan, a complex tango.Science translational medicine · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Marta ZampinoNational Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.ORCID 0000-0002-9381-3291
Majd AlGhatrifNational Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Pei-Lun KuoNational Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Eleanor Marie SimonsickNational Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Luigi FerrucciNational Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
National Institutes of Health · US

Funding

NIA NIH HHS Intramural Research Program
6 · The paper itself

Abstract

Resting metabolic rate (RMR) declines with aging and is related to changes in health status, but how specific health impairments impact basal metabolism over time has been largely unexplored. We analyzed the association of RMR with 15 common age-related chronic diseases for up to 13 years of follow-up in a population of 997 participants to the Baltimore Longitudinal Study of Aging. At each visit, participants underwent measurements of RMR by indirect calorimetry and body composition by DEXA. Linear regression models and linear mixed effect models were used to test cross-sectional and longitudinal associations of RMR and changes in disease status. Several diseases were associated with higher RMR at baseline. Independent of covariates, prevalent COPD and cancer, as well as incident diabetes, heart failure, and CKD were associated with a steeper decline in RMR over time. Chronic diseases seem to have a two-phase association with RMR. Initially, RMR may increase because of the high cost of resiliency homeostatic mechanisms. However, as the reserve capacity becomes exhausted, a catabolic cascade becomes unavoidable, resulting in loss of total and metabolically active mass and consequent RMR decline.

Indexed as

Basal MetabolismHealth StatusAgingBaltimoreBody CompositionCalorimetry, IndirectChronic DiseaseCross-Sectional StudiesDiabetes MellitusFemaleFollow-Up StudiesHeart FailureHomeostasisHumansLinear ModelsLongitudinal Studiesagingbody compositionchronic diseasesresting metabolic rate

Identifiers

PMID33036360
PMCPMC7600750
OpenAlexW3092581708

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.