Evidence map›Paper›PMID 33036278›Full record

ArticleViruses2020

Highly Immunogenic Nanoparticles Based on a Fusion Protein Comprising the M2e of Influenza A Virus and a Lipopeptide.

Anna A Zykova, Elena A Blokhina, Roman Y Kotlyarov, Liudmila A Stepanova, Liudmila M Tsybalova, Victor V Kuprianov, Nikolai V Ravin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Anna A ZykovaInstitute of Bioengineering, Research Center of Biotechnology of the Russian Academy of Sciences, Moscow 119071, Russia.
Elena A BlokhinaInstitute of Bioengineering, Research Center of Biotechnology of the Russian Academy of Sciences, Moscow 119071, Russia.
Roman Y KotlyarovInstitute of Bioengineering, Research Center of Biotechnology of the Russian Academy of Sciences, Moscow 119071, Russia.
Liudmila A StepanovaResearch Institute of Influenza, Russian Ministry of Health, St. Petersburg 23805, Russia.
Liudmila M TsybalovaResearch Institute of Influenza, Russian Ministry of Health, St. Petersburg 23805, Russia.
Victor V KuprianovInstitute of Bioengineering, Research Center of Biotechnology of the Russian Academy of Sciences, Moscow 119071, Russia.
Nikolai V RavinInstitute of Bioengineering, Research Center of Biotechnology of the Russian Academy of Sciences, Moscow 119071, Russia.
Russian Academy of Sciences · RUMinistry of Health of the Russian Federation · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The highly conserved extracellular domain of the transmembrane protein M2 (M2e) of the influenza A virus is a promising target for the development of broad-spectrum vaccines. However, M2e is a poor immunogen by itself and must be linked to an appropriate carrier to induce an efficient immune response. In this study, we obtained recombinant mosaic proteins containing tandem copies of M2e fused to a lipopeptide from

Indexed as

AnimalsBacterial ProteinsDisease Models, AnimalFemaleHumansInfluenza A virusInfluenza, HumanInfluenza VaccinesLipopeptidesMembrane Fusion ProteinsMiceMice, Inbred BALB CNanoparticlesNeisseria meningitidisOrthomyxoviridae InfectionsProtein DomainsBacterial ProteinsInfluenza VaccinesLipopeptidesMembrane Fusion ProteinsM-protein, influenza virusNMB1468 protein, Neisseria meningitidisRecombinant Fusion ProteinsVaccines, SyntheticViral Matrix ProteinsinfluenzalipopeptideM2e peptidenanoparticlerecombinant vaccine

Identifiers

PMID33036278
PMCPMC7601894
OpenAlexW3092405408

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.