Evidence map›Paper›PMID 33036232›Full record

ArticleGenes2020

Detargeting Lentiviral-Mediated CFTR Expression in Airway Basal Cells Using miR-106b.

Soon H Choi, Rosie E Reeves, Guillermo S Romano Ibarra, Thomas J Lynch, Weam S Shahin, Zehua Feng, Grace N Gasser, Michael C Winter, T Idil Apak Evans, Xiaoming Liu and 6 more

Open access · goldAbstract read
In one paragraph

Article in Genes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Considerations for early life genetic therapies in cystic fibrosis.American journal of physiology. Lung cellular and molecular physiology · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Soon H ChoiDepartment of Anatomy and Cell Biology, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA.ORCID 0000-0002-2351-9775
Rosie E ReevesDepartment of Anatomy and Cell Biology, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA.
Guillermo S Romano IbarraMolecular Medicine Program, University of Iowa, Carver College of Medicine, Iowa City, IA 52246, USA.
Thomas J LynchDepartment of Anatomy and Cell Biology, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA.
Weam S ShahinDepartment of Anatomy and Cell Biology, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA.
Zehua FengDepartment of Anatomy and Cell Biology, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA.
Grace N GasserDepartment of Anatomy and Cell Biology, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA.
Michael C WinterDepartment of Anatomy and Cell Biology, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA.
T Idil Apak EvansDepartment of Anatomy and Cell Biology, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA.
Xiaoming LiuDepartment of Anatomy and Cell Biology, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA.
Meihui LuoDepartment of Anatomy and Cell Biology, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA.
Yulong ZhangDepartment of Anatomy and Cell Biology, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA.
David A StoltzDepartment of Internal Medicine, University of Iowa, Carver College of Medicine, Iowa City, IA 52246, USA.
Eric J DevorDepartment of Obstetrics and Gynecology, University of Iowa, Carver College of Medicine, Iowa City, IA 52246, USA.
Ziying YanDepartment of Anatomy and Cell Biology, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA.ORCID 0000-0001-8210-5567
John F EngelhardtDepartment of Anatomy and Cell Biology, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA.
University of Iowa · US

Funding

Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5M
Vector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Amy Leanne Ryan · 1998 to 2026
$30.5M
Multidisciplinary Lung Research Career Development ProgramT32HL007638 · NHLBI · UNIVERSITY OF IOWA · PI WELSH, MICHAEL J., ZABNER, JOSEPH · 1986 to 2020
$16.9M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007337 · NIGMS · UNIVERSITY OF IOWA · PI GEYER, PAMELA K., LENTZ, STEVEN R · 1985 to 2020
$15.9M
Pathology CoreP01HL152960 · NHLBI · UNIVERSITY OF IOWA · PI ENGELHARDT, JOHN F · 2020 to 2024
$11.6M
MODELS OF SUBMUCOSAL GLAND DEVELOPMENT AND FUNCTIONR01DK047967 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI ENGELHARDT, JOHN F · 1993 to 2020
$3.8M
Biology of Submucosal Gland Stem Cells in the AirwayR01HL165404 · NHLBI · UNIVERSITY OF IOWA · PI ENGELHARDT, JOHN F · 2022 to 2025
$2.9M
NHLBI NIH HHS P01 HL152960NHLBI NIH HHS R01 HL165404NIDDK NIH HHS P30 DK054759NIDDK NIH HHS R01 DK047967NIEHS NIH HHS P30 ES005605NIGMS NIH HHS T32 GM007337NIH HHS P01 HL152960NIH HHS R01 DK047967NIH HHS T32 HL007638
6 · The paper itself

Abstract

Lentiviral-mediated integration of a

Indexed as

Gene Expression RegulationCell DifferentiationCystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorEpithelial CellsGenetic VectorsHEK293 CellsHumansLentivirusMicroRNAsRespiratory MucosaStem CellsCFTR protein, humanCystic Fibrosis Transmembrane Conductance RegulatorMicroRNAsMIRN106 microRNA, humanairway basal cellCFTRgene therapylentivirusmiRNA

Identifiers

PMID33036232
PMCPMC7601932
OpenAlexW3092067274

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.