Evidence map›Paper›PMID 33036212›Full record

ArticleAntibodies (Basel, Switzerland)2020

Anti gC1qR/p32/HABP1 Antibody Therapy Decreases Tumor Growth in an Orthotopic Murine Xenotransplant Model of Triple Negative Breast Cancer.

Ellinor I Peerschke, Elisa de Stanchina, Qing Chang, Katia Manova-Todorova, Afsar Barlas, Anne G Savitt, Brian V Geisbrecht, Berhane Ghebrehiwet

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antibodies (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. gC1qR: A New Target for Cancer Immunotherapy.Frontiers in immunology · 2023
    Review
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Ellinor I PeerschkeDepartment of Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.ORCID 0000-0001-5440-472X
Elisa de StanchinaSloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Qing ChangSloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Katia Manova-TodorovaSloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Afsar BarlasSloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Anne G SavittDepartment of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA.ORCID 0000-0002-5604-5393
Brian V GeisbrechtDepartment of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS 66506, USA.
Berhane GhebrehiwetDepartments of Medicine and Pathology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA.
Memorial Sloan Kettering Cancer Center · USStony Brook School · USKansas State University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
gC1q-R/p33: structure function and role on inflammation.R01AI060866 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI GHEBREHIWET, BERHANE · 2006 to 2009
$1.2M
The role of C1q in regulation of monocyte to dendritic cell transitionR01AI084178 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI GHEBREHIWET, BERHANE · 2009 to 2010
$602k
National Institutes of Allergy and Infectious Diseases RO1 AI 060866National Institutes of Allergy and Infectious Diseases RO1 AI 084178NCI NIH HHS P30 CA008748Terry Johnson Cancer Research Center N/A
6 · The paper itself

Abstract

gC1qR is highly expressed in breast cancer and plays a role in cancer cell proliferation. This study explored therapy with gC1qR monoclonal antibody 60.11, directed against the C1q binding domain of gC1qR, in a murine orthotopic xenotransplant model of triple negative breast cancer. MDA231 breast cancer cells were injected into the mammary fat pad of athymic nu/nu female mice. Mice were segregated into three groups (

Indexed as

breast cancergC1qRxenotransplant model

Identifiers

PMID33036212
PMCPMC7709104
OpenAlexW3092424195

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.