ArticlePediatric research2021
Uric acid reference values: report on 1750 healthy Brazilian children and adolescents.
Article in Pediatric research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 24 citations in OpenAlex.
- Serum uric acid levels among children and adolescents in China: percentile reference values and national prevalence estimates of hyperuricemia.BMC medicine · 2026Article
- Trends in serum uric acid among US adolescents.Pediatric research · 2026Article
- Dietary management of pediatric patients with kidney disease: recommendations by the Korean Society of Pediatric Nephrology and the Korean Society of Clinical Nutrition.Childhood kidney diseases · 2026Article
- Serum uric acid in pediatric metabolic assessment: the scientific rationale for routine screening and the urgent need for age- and sex-specific diagnostic thresholds.Frontiers in nephrology · 2026Article
- Dietary management of pediatric patients with kidney disease: recommendations by the Korean Society of Pediatric Nephrology and the Korean Society of Clinical Nutrition.Clinical nutrition research · 2026Article
- Pediatric hyperuricemia: genetic basis, metabolic mechanisms, and clinical implications.Frontiers in endocrinology · 2026Review
- Serum uric acid level as a marker associated with microalbuminuria in pediatric patients with type 1 diabetes mellitus.European journal of pediatrics · 2025Article
- Dietary management of pediatric patients with kidney disease: recommendations by The Korean Society of Pediatric Nephrology and The Korean Society of Clinical Nutrition.Kidney research and clinical practice · 2025Article
- Association Between Hyperuricemia, Body Composition, and Comorbidities in an Obese Pediatric Population.Journal of nutrition and metabolism · 2025Article
- Triponderal mass index can be used as a potential tool to predict the risk of hyperuricemia in children and adolescents with obesity: a population-based study.Frontiers in nutrition · 2025Article
- Uric acid and unhealthy metabolic phenotype in Colombian children.Pediatric endocrinology, diabetes, and metabolism · 2025Article
- Gender Influence on XOR Activities and Related Pathologies: A Narrative Review.Antioxidants (Basel, Switzerland) · 2024Review
- Association between serum uric acid and triglyceride-glucose index in children and adolescents with short stature.Scientific reports · 2023Article
- Elevated serum uric acid is associated with the risk of advanced staging and vascular involvement in patients with hepatoblastoma: a 14-year retrospective study.Frontiers in oncology · 2023Article
- Associations between body mass index in different childhood age periods and hyperuricemia in young adulthood: the China Health and Nutrition Survey cohort study.World journal of pediatrics : WJP · 2022Article
- Uric acid and cardiometabolic risk by gender in youth with type 1 diabetes.Scientific reports · 2022Article
- Impact of Lifestyle Modifications on Alterations in Lipid and Glycemic Profiles and Uric Acid Values in a Pediatric Population.Nutrients · 2022Article
- Association Between Serum Uric Acid Levels and Suicide Attempts in Adolescents and Young Adults with Major Depressive Disorder: A Retrospective Study.Neuropsychiatric disease and treatment · 2022Article
- Association of obesity phenotypes with left ventricular mass index and left ventricular hypertrophy in children and adolescents.Frontiers in endocrinology · 2022Article
- Analysis of the prevalence and influencing factors of hyperuricemia in children and adolescents aged 6-17 years in northeastern Sichuan Province.Jornal de pediatriaArticle
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Authors and funding
6 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundOur purpose was to determine reference values and determinants of serum uric acid (SUA) in children and adolescents.
methodsA fasting blood sample was collected from 1750 schoolchildren and adolescents (6-17 years). Puberty was defined according to the Tanner scale. Bodyweight, muscle mass, and body fat percentage were determined by bioimpedance. Data are given as cut-offs and mean ± standard deviation.
resultsSUA level was higher in children that had already entered puberty (4.2 ± 1.1 mg/dL) than among prepubescent (3.6 ± 0.8 mg/dL; p < 0.01). Considering the 90 percentile (p90) as the upper reference value, the following values are proposed for boys and girls, respectively: <10 years or prepubescent: ≤4.5 mg/dL and ≤4.8 mg/dL; from 10 to 13 years: ≤5.7 mg/dL and ≤5.2 mg/dL; from 14 to 17 years: ≤6.4 mg/dL and ≤5.3 mg/dL. Muscle mass explained part of the variability in SUA after pubescence, acting as an independent variable for higher levels of SUA.
conclusionsThe sex, age, and phase of puberty influence SUA reference levels, and part of this influence could be explained by the higher muscle mass, mainly after the adolescence onset. IMPACT: The key message of this study is that high levels of uric acid in the blood are associated with metabolic syndrome and cardiovascular risk factors. These diseases should be prevented since the infancy However, it is necessary to establish reference values of uric acid (SUA) for children and adolescents. The Brazilian population is highly admixed and these values were not determined so far. We studied a robust sample of Brazilian schoolchildren and adolescents (6-17 years) and defined the 90th percentile of uric acid as the upper limit of normality for sex, age, and pubertal stage. These values can be used as a reference for other populations with similar characteristics.
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