Evidence map›Paper›PMID 33036015›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2021

A novel allosteric modulator of the cannabinoid CB

Catharine A Mielnik, Kim S Sugamori, David B Finlay, Hayley H A Thorpe, Matthieu Schapira, Nirunthan Sivananthan, Chun Kit Li, Vincent M Lam, Sean Harrington, Mostafa H Abdelrahman and 8 more

Open access · hybridAbstract read
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 3 countries.

Catharine A MielnikUniversity of Toronto, Faculty of Medicine, Department of Pharmacology & Toxicology, Toronto, ON, Canada.ORCID http://orcid.org/0000-0002-4362-8987
Kim S SugamoriUniversity of Toronto, Faculty of Medicine, Department of Pharmacology & Toxicology, Toronto, ON, Canada.
David B FinlayUniversity of Otago, Department of Pharmacology & Toxicology, Dunedin, New Zealand.
Hayley H A ThorpeUniversity of Guelph, Department of Biomedical Sciences, Guelph, ON, Canada.
Matthieu SchapiraStructural Genomics Consortium, University of Toronto, Toronto, ON, Canada.
Nirunthan SivananthanUniversity of Toronto, Faculty of Medicine, Department of Pharmacology & Toxicology, Toronto, ON, Canada.ORCID http://orcid.org/0000-0002-5689-1514
Chun Kit LiUniversity of Toronto, Faculty of Medicine, Department of Pharmacology & Toxicology, Toronto, ON, Canada.
Vincent M LamUniversity of Toronto, Faculty of Medicine, Department of Pharmacology & Toxicology, Toronto, ON, Canada.
Sean HarringtonUniversity of Toronto, Faculty of Medicine, Department of Pharmacology & Toxicology, Toronto, ON, Canada.
Mostafa H AbdelrahmanUniversity of Aberdeen, Aberdeen, UK.
Laurent A TrembleauUniversity of Aberdeen, Aberdeen, UK.
W McIntyre BurnhamUniversity of Toronto, Faculty of Medicine, Department of Pharmacology & Toxicology, Toronto, ON, Canada.
Jibran Y KhokharUniversity of Guelph, Department of Biomedical Sciences, Guelph, ON, Canada.
Ali SalahpourUniversity of Toronto, Faculty of Medicine, Department of Pharmacology & Toxicology, Toronto, ON, Canada.
Amy J RamseyUniversity of Toronto, Faculty of Medicine, Department of Pharmacology & Toxicology, Toronto, ON, Canada.ORCID http://orcid.org/0000-0002-2717-5279
Michelle GlassUniversity of Otago, Department of Pharmacology & Toxicology, Dunedin, New Zealand.
Iain R GreigUniversity of Aberdeen, Aberdeen, UK.
Ruth A RossUniversity of Toronto, Faculty of Medicine, Department of Pharmacology & Toxicology, Toronto, ON, Canada. ruth.ross@utoronto.ca.
University of Toronto · CAUniversity of Aberdeen · GBUniversity of Guelph · CAUniversity of Otago · NZ

Funding

CIHR MOP119298CIHR PJT-15619CIHR PP2-139101CIHR PPP-125784
6 · The paper itself

Abstract

The endocannabinoid system (eCBs) encompasses the endocannabinoids, their synthetic and degradative enzymes, and cannabinoid (CB) receptors. The eCBs mediates inhibition of neurotransmitter release and acts as a major homeostatic system. Many aspects of the eCBs are altered in a number of psychiatric disorders including schizophrenia, which is characterized by dysregulation of dopaminergic signaling. The GluN1-Knockdown (GluN1KD) and Dopamine Transporter Knockout (DATKO) mice are models of hyperdopaminergia, which display abnormal psychosis-related behaviors, including hyperlocomotion and changes in pre-pulse inhibition (PPI). Here, we investigate the ability of a novel CB

Indexed as

CannabinoidsEndophenotypesAnimalsMiceMice, KnockoutReceptor, Cannabinoid, CB1Receptors, CannabinoidRodentiaCannabinoidsReceptor, Cannabinoid, CB1Receptors, Cannabinoid

Identifiers

PMID33036015
PMCPMC7852560
OpenAlexW3082176809

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.