ArticleBrain stimulation
Real-time suppression and amplification of frequency-specific neural activity using stimulation evoked oscillations.
Article in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Excessive daytime sleepiness in parkinsonism is associated with cortical and basal ganglia beta oscillatory activity.Communications biology · 2026Article
- Effect of frequency on dual target deep brain stimulation.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026Article
- Alterations in beta oscillatory activity occur with the emergence of parkinsonian motor signs across the basal ganglia-thalamocortical network.Neurobiology of disease · 2025Article
- Article
- Deep brain stimulation pulse sequences to optimally modulate frequency-specific neural activity.Journal of neural engineering · 2024Article
- High-Frequency Local Field Potential Oscillations for Pigeons in Effective Turning.Animals : an open access journal from MDPI · 2024Article
- Development and Evaluation of a Real-Time Phase-Triggered Stimulation Algorithm for the CorTec Brain Interchange.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2024Article
- Closing the loop in psychiatric deep brain stimulation: physiology, psychometrics, and plasticity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Neurophysiological mechanisms of deep brain stimulation across spatiotemporal resolutions.Brain : a journal of neurology · 2023Review
- Classification of electrically-evoked potentials in the parkinsonian subthalamic nucleus region.Scientific reports · 2023Article
- Low-frequency deep brain stimulation reveals resonant beta-band evoked oscillations in the pallidum of Parkinson's Disease patients.Frontiers in human neuroscience · 2023Article
- Parkinsonian daytime sleep-wake classification using deep brain stimulation lead recordings.Neurobiology of disease · 2023Article
- Stable, interactive modulation of neuronal oscillations produced through brain-machine equilibrium.Cell reports · 2022Article
- Spontaneous Spiking Is Governed by Broadband Fluctuations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Stimulating at the right time to recover network states in a model of the cortico-basal ganglia-thalamic circuit.PLoS computational biology · 2022Article
- Toolkit for Oscillatory Real-time Tracking and Estimation (TORTE).Journal of neuroscience methods · 2022Article
- The impact of pulse timing on cortical and subthalamic nucleus deep brain stimulation evoked potentials.Frontiers in human neuroscience · 2022Article
- Correlated Activity in the Degenerate Retina Inhibits Focal Response to Electrical Stimulation.Frontiers in cellular neuroscience · 2022Article
- Identifying and modulating distinct tremor states through peripheral nerve stimulation in Parkinsonian rest tremor.Journal of neuroengineering and rehabilitation · 2021Article
- Essential tremor amplitude modulation by median nerve stimulation.Scientific reports · 2021Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
backgroundApproaches to predictably control neural oscillations are needed to understand their causal role in brain function in healthy or diseased states and to advance the development of neuromodulation therapies.
objectiveWe present a closed-loop neural control and optimization framework to actively suppress or amplify low-frequency neural oscillations observed in local field potentials in real-time by using electrical stimulation. The rationale behind this control approach and our working hypothesis is that neural oscillatory activity evoked by electrical pulses can suppress or amplify spontaneous oscillations via destructive or constructive interference when the pulses are continuously delivered with appropriate amplitudes and at precise phases of the modulated oscillations in a closed-loop scheme.
methodsWe tested our hypothesis in two nonhuman primates that exhibited a robust increase in low-frequency (8-30 Hz) oscillatory power in the subthalamic nucleus (STN) following administration of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). To test our neural control approach, we targeted 8-17 Hz oscillations and used electrode arrays and electrical stimulation waveforms similar to those used in humans chronically implanted with brain stimulation systems. Stimulation parameters that maximize the suppression or amplification of neural oscillations were predicted using mathematical models of the stimulation evoked oscillations.
resultsOur neural control and optimization approach was capable of actively and robustly suppressing or amplifying oscillations in the targeted frequency band (8-17 Hz) in real-time in the studied subjects.
conclusionsThe results from this study support our hypothesis and suggest that the proposed neural control framework allows one to characterize in controlled experiments the functional role of frequency-specific neural oscillations by using electrodes and stimulation waveforms currently being employed in humans.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.