ArticleCell metabolism2020
Dissociation of Muscle Insulin Resistance from Alterations in Mitochondrial Substrate Preference.
Open access · bronzeAbstract read
In one paragraph
Article in Cell metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 43 citations in OpenAlex.
- Determinants of increased muscle insulin sensitivity of exercise-trained versus sedentary normal weight and overweight individuals.Science advances · 2025Trial
- Molecular mechanisms and pathogenesis of MASH.Nature · 2026Review
- Insulin receptorNature communications · 2026Article
- Precancer exercise capacity and metabolism during tumor development coordinate the skeletal muscle-tumor metabolic competition.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Transcriptomic and epigenomic signatures of liver metabolism and insulin sensitivity in aging mice.Mechanisms of ageing and development · 2025Article
- Simultaneous in vivo multi-organ fluxomics reveals divergent metabolic adaptations in liver, heart, and skeletal muscle during obesity.Cell reports · 2025Article
- Metabolic rewiring in skin epidermis drives tolerance to oncogenic mutations.Nature cell biology · 2025Article
- Impaired suppression of fatty acid release by insulin is a strong predictor of reduced whole-body insulin-mediated glucose uptake and skeletal muscle insulin receptor activation.Acta physiologica (Oxford, England) · 2025Article
- SGLT2 inhibition alters substrate utilization and mitochondrial redox in healthy and failing rat hearts.The Journal of clinical investigation · 2024Article
- Reducing the mitochondrial oxidative burden alleviates lipid-induced muscle insulin resistance in humans.Science advances · 2024Article
- Small molecule inhibition of glycogen synthase I reduces muscle glycogen content and improves biomarkers in a mouse model of Pompe disease.American journal of physiology. Endocrinology and metabolism · 2024Article
- Glucose Load Following Prolonged Fasting Increases Oxidative Stress- Linked Response in Individuals With Diabetic Complications.Diabetes care · 2024Article
- Article
- Intramuscular diacylglycerol accumulates with acute hyperinsulinemia in insulin-resistant phenotypes.American journal of physiology. Endocrinology and metabolism · 2024Article
- Article
- Distinct subcellular localisation of intramyocellular lipids and reduced PKCε/PKCθ activity preserve muscle insulin sensitivity in exercise-trained mice.Diabetologia · 2023Article
- Perhexiline Therapy in Patients with Type 2 Diabetes: Incremental Insulin Resistance despite Potentiation of Nitric Oxide Signaling.Biomedicines · 2022Article
- Mitochondria-Mediated Cardiovascular Benefits of Sodium-Glucose Co-Transporter 2 Inhibitors.International journal of molecular sciences · 2022Review
- Bioactive lipids and metabolic syndrome-a symposium report.Annals of the New York Academy of Sciences · 2022Article
- In vivoCurrent opinion in biotechnology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 1 institution in 3 countries.
Joongyu D SongDepartment of Medicine, Yale School of Medicine, New Haven, CT, USA.
Tiago C AlvesDepartment of Medicine, Yale School of Medicine, New Haven, CT, USA.
Douglas E BefroyDepartment of Medicine, Yale School of Medicine, New Haven, CT, USA; Department of Radiology & Bioengineering, Yale School of Medicine, New Haven, CT, USA; PeakAnalysts, Benenden, Kent, UK.
Rachel J PerryDepartment of Medicine, Yale School of Medicine, New Haven, CT, USA; Department of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT, USA.
Graeme F MasonDepartment of Radiology & Bioengineering, Yale School of Medicine, New Haven, CT, USA; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Xian-Man ZhangDepartment of Medicine, Yale School of Medicine, New Haven, CT, USA.
Alexander MunkDepartment of Medicine, Yale School of Medicine, New Haven, CT, USA.
Ye ZhangDepartment of Medicine, Yale School of Medicine, New Haven, CT, USA.
Dongyan ZhangDepartment of Medicine, Yale School of Medicine, New Haven, CT, USA.
Gary W ClineDepartment of Medicine, Yale School of Medicine, New Haven, CT, USA.
Douglas L RothmanDepartment of Radiology & Bioengineering, Yale School of Medicine, New Haven, CT, USA.
Kitt Falk PetersenDepartment of Medicine, Yale School of Medicine, New Haven, CT, USA; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark. Electronic address: kitt.petersen@yale.edu.
Gerald I ShulmanDepartment of Medicine, Yale School of Medicine, New Haven, CT, USA; Department of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT, USA. Electronic address: gerald.shulman@yale.edu.
Yale University · US
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MYale Diabetes Research CenterP30DK045735 · NIDDK · YALE UNIVERSITY · PI GERALD I SHULMAN · 1993 to 2026
$44.0MYale University Clinical and Translational Science Award ProgramUL1TR000142 · NCATS · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2012 to 2015
$31.8MYale Mouse Metabolic Phenotyping CenterU24DK059635 · NIDDK · YALE UNIVERSITY · PI SHULMAN, GERALD I · 2001 to 2015
$8.9MRole of Mitochondrial Dysfunction in Insulin ResistanceP01DK068229 · NIDDK · YALE UNIVERSITY · PI SHULMAN, GERALD I · 2004 to 2008
$7.0MGenetic and Cellular Mechanisms of NAFLD and Hepatic Insulin ResistanceR24DK085638 · NIDDK · YALE UNIVERSITY · PI SHULMAN, GERALD I · 2010 to 2014
$6.3MNMR STUDIES OF GLYCOGEN METABOLISM IN HUMANSR01DK049230 · NIDDK · YALE UNIVERSITY · PI SHULMAN, GERALD I · 1995 to 2014
$5.4MMechanisms of Lipid-Induced Hepatic Insulin ResistanceR01DK040936 · NIDDK · YALE UNIVERSITY · PI SHULMAN, GERALD I · 1989 to 2015
$5.1MEffects of Hepatic Acetyl-CoA Carboxylase Inhibition on NAFLD and Hepatic Insulin ResistanceR01DK113984 · NIDDK · YALE UNIVERSITY · PI SHULMAN, GERALD I · 2017 to 2021
$3.7MBrain Acetate and Ethanol Metabolism in Alcohol Dependence and AbuseR01AA021984 · NIAAA · YALE UNIVERSITY · PI MASON, GRAEME F. · 2013 to 2017
$2.7MDevelopment of Controlled Release Mitochondrial Protonophore (CRMP) as a Novel Treatment for Type-2 Diabetes and Non-Alcoholic Steatohepatitis in Dysmetabolic Non-Human PrimatesR01DK119968 · NIDDK · YALE UNIVERSITY · PI SHULMAN, GERALD I · 2019 to 2024
$2.7MMicrobiome origins and insulin regulatory responses of the short chain fatty acid acetateR01DK114793 · NIDDK · YALE UNIVERSITY · PI GOODMAN, ANDREW L, SHULMAN, GERALD I · 2018 to 2021
$2.4MNCATS NIH HHS UL1 TR000142NCATS NIH HHS UL1 TR001863NCI NIH HHS R00 CA215315NIAAA NIH HHS R01 AA021984NIDDK NIH HHS P01 DK068229NIDDK NIH HHS P30 DK045735NIDDK NIH HHS R01 DK040936NIDDK NIH HHS R01 DK049230NIDDK NIH HHS R01 DK108283NIDDK NIH HHS R01 DK113984NIDDK NIH HHS R01 DK114793NIDDK NIH HHS R01 DK116774NIDDK NIH HHS R01 DK119968NIDDK NIH HHS R24 DK085638NIDDK NIH HHS T32 DK101019NIDDK NIH HHS U24 DK059635NINDS NIH HHS R01 NS087568
Abstract
Alterations in muscle mitochondrial substrate preference have been postulated to play a major role in the pathogenesis of muscle insulin resistance. In order to examine this hypothesis, we assessed the ratio of mitochondrial pyruvate oxidation (V
Indexed as
AdultAnimalsHumansInsulin ResistanceMaleMitochondriaMuscle, SkeletalRatsRats, Sprague-Dawleycitrate synthaseglucose oxidationinsulin resistancemetabolic fluxmetabolic inflexibilitymitochondriamuscle metabolismpyruvate dehydrogenaseRandle Cyclerespiratory quotient
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.