Evidence map›Paper›PMID 33035434›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2020

Extracellular vesicles: new players in regulating vascular barrier function.

Victor Chatterjee, Xiaoyuan Yang, Yonggang Ma, Mack H Wu, Sarah Y Yuan

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 66 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Victor ChatterjeeDepartment of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, Florida.
Xiaoyuan YangDepartment of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, Florida.
Yonggang MaDepartment of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, Florida.
Mack H WuDepartment of Surgery, University of South Florida Morsani College of Medicine, Tampa, Florida.
Sarah Y YuanDepartment of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, Florida.
University of South Florida · US

Funding

Vascular Barrier Leakage in InflammationR35HL150732 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI Sarah Y Yuan · 2020 to 2026
$6.2M
Disintegrin Metalloprotease and Endothelial PermeabilityR01GM097270 · NIGMS · UNIVERSITY OF SOUTH FLORIDA · PI YUAN, SARAH Y · 2011 to 2020
$2.3M
Endothelial focal adhesions in microvascular barrier dysfunction during ischemia-R01HL120954 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI WU, MACK H · 2014 to 2017
$1.5M
BLRD VA I01 BX000799BLRD VA IK6 BX004210NHLBI NIH HHS R01 HL120954NHLBI NIH HHS R35 HL150732NIGMS NIH HHS R01 GM097270
6 · The paper itself

Abstract

Extracellular vesicles (EVs) have attracted rising interests in the cardiovascular field not only because they serve as serological markers for circulatory disorders but also because they participate in important physiological responses to stress and inflammation. In the circulation, these membranous vesicles are mainly derived from blood or vascular cells, and they carry cargos with distinct molecular signatures reflecting the origin and activation state of parent cells that produce them, thus providing a powerful tool for diagnosis and prognosis of pathological conditions. Functionally, circulating EVs mediate tissue-tissue communication by transporting bioactive cargos to local and distant sites, where they directly interact with target cells to alter their function. Recent evidence points to the critical contributions of EVs to the pathogenesis of vascular endothelial barrier dysfunction during inflammatory response to injury or infection. In this review, we provide a brief summary of the current knowledge on EV biology and advanced techniques in EV isolation and characterization. This is followed by a discussion focusing on the role and mechanisms of EVs in regulating blood-endothelium interactions and vascular permeability during inflammation. We conclude with a translational perspective on the diagnostic and therapeutic potential of EVs in vascular injury or infectious diseases, such as COVID-19.

Indexed as

Capillary PermeabilityAnimalsBetacoronavirusCoronavirus InfectionsCOVID-19Endothelium, VascularExtracellular VesiclesHost-Pathogen InteractionsHumansInflammationInflammation MediatorsPandemicsPneumonia, ViralSARS-CoV-2Signal TransductionInflammation Mediatorsendothelial permeabilityexosomesinflammationmicrovesicles

Identifiers

PMID33035434
PMCPMC7792704
OpenAlexW3092533056

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.