Evidence map›Paper›PMID 33035432›Full record

ReviewAnnual review of medicine2021

Synchronizing Brain Rhythms to Improve Cognition.

Shrey Grover, John A Nguyen, Robert M G Reinhart

Open access · bronzeAbstract readReview
In one paragraph

Review in Annual review of medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 2 pooled it
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 95 citations in OpenAlex.

  1. Pooled it
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  7. Article
  8. Cortical synchrony is reduced in Alzheimer's disease and relates to arousal state.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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  17. Neurostimulation to Improve Cognitive Flexibility.Current opinion in behavioral sciences · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Shrey GroverDepartment of Psychological & Brain Sciences, Boston University, Boston, Massachusetts 02215, USA; email: grovers@bu.edu, akida@bu.edu, rmgr@bu.edu.
John A NguyenDepartment of Psychological & Brain Sciences, Boston University, Boston, Massachusetts 02215, USA; email: grovers@bu.edu, akida@bu.edu, rmgr@bu.edu.
Robert M G ReinhartDepartment of Psychological & Brain Sciences, Boston University, Boston, Massachusetts 02215, USA; email: grovers@bu.edu, akida@bu.edu, rmgr@bu.edu.
Boston University · US

Funding

Improving Working Memory in Older Adults by Restoring Large-Scale Cortical InteractionsR01AG063775 · NIA · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI REINHART, ROBERT · 2019 to 2023
$2.1M
Causal Restructuring of Neural Rhythms Improves Adaptive BehaviorR01MH114877 · NIMH · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI REINHART, ROBERT · 2018 to 2022
$2.1M
NIA NIH HHS R01 AG063775NIMH NIH HHS R01 MH114877
6 · The paper itself

Abstract

Impaired cognition is common in many neuropsychiatric disorders and severely compromises quality of life. Synchronous electrophysiological rhythms represent a core mechanism for sculpting communication dynamics among large-scale brain networks that underpin cognition and its breakdown in neuropsychiatric disorders. Here, we review an emerging neuromodulation technology called transcranial alternating current stimulation that has shown remarkable early results in rapidly improving various domains of human cognition by modulating properties of rhythmic network synchronization. Future noninvasive neuromodulation research holds promise for potentially rescuing network activity patterns and improving cognition, setting groundwork for the development of drug-free, circuit-based therapeutics for people with cognitive brain disorders.

Indexed as

BrainCircadian RhythmCognitionCognition DisordersHumansTranscranial Direct Current Stimulationcognitioncognitive deficitscross-frequency couplingneuropsychiatric disorderssynchronizationtranscranial alternating current stimulation

Identifiers

PMID33035432
PMCPMC10068593
OpenAlexW3091893954

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.