ArticleJournal of clinical hypertension (Greenwich, Conn.)2020
Association between serum albumin and peripheral arterial disease in hypertensive patients.
Article in Journal of clinical hypertension (Greenwich, Conn.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Serum Albumin and Uric Acid Levels Among Hypertensive Patients in Northwest Ethiopia: A Comparative Cross-Sectional Study.Health science reports · 2026Article
- A new information integration framework for complex models with applications to real-world data.Statistical methods in medical research · 2026Article
- Article
- Risk factors of major lower limb amputation in symptomatic peripheral artery disease: a retrospective cohort study.Future science OA · 2025Article
- Clinical management of peripheral arterial disease in chronic kidney disease-a comprehensive review from the European Renal Association CKD-MBD Working Group.Clinical kidney journal · 2025Review
- Predictive Value of the Neutrophil-to-Lymphocyte Ratio/Serum Albumin for All-Cause Mortality in Critically Ill Patients Suffering from COPD.International journal of chronic obstructive pulmonary disease · 2025Article
- The relationship between CALLY index and stroke in hypertensive patients: insights from NHANES.Frontiers in nutrition · 2025Article
- Association between red cell distribution width-and-albumin ratio and the risk of peripheral artery disease in patients with diabetes.Frontiers in endocrinology · 2024Article
- Platelet-hemoglobin ratio predicts amputation in patients with below-knee peripheral arterial disease.BMC cardiovascular disorders · 2022Article
- Serum albumin was negatively associated with diabetic peripheral neuropathy in Chinese population: a cross-sectional study.Diabetology & metabolic syndrome · 2021Article
- Association between serum albumin and peripheral arterial disease in hypertensive patients.Journal of clinical hypertension (Greenwich, Conn.) · 2020Article
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The authors aimed to evaluate the relationship of serum albumin with peripheral arterial disease (PAD) and investigate any possible effect modifiers in hypertensive patients. In the cross-sectional study, a total of 10,900 Chinese hypertensive patients aged ≥18 years were enrolled. The outcome was PAD, defined as an ankle-brachial index (ABI) <0.90 in either leg. The overall mean (SD) serum albumin was 46.8 (4.2) g/L. There were significant inverse associations of serum albumin with PAD (per SD increment; OR: 0.83; 95% CI: 0.72, 0.94). Compared with the lowest tertile (<45.1 g/L), the multivariate-adjusted ORs (95% CI) for participants in the middle tertile (45.1-48.2 g/L) and highest tertile (≥48.2 g/L) of serum albumin were 0.89 (95% CI: 0.67, 1.16) and 0.65 (95% CI: 0.47, 0.90), respectively. Conversely, lower albumin (<48.2 g/L) concentrations were associated with increased odds of PAD (OR: 1.45; 95% CI: 1.08-1.96) compared with higher concentrations. Furthermore, the albumin-PAD association was significantly stronger in males (OR: 2.08; 95% CI: 1.31, 3.30) than in females (OR: 1.06; 95% CI: 0.70, 1.58; p interaction = .024). In conclusion, among Chinese hypertensive adults, lower serum albumin was associated with the prevalence of PAD only in males but not in females.
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