Evidence map›Paper›PMID 33035386›Full record

ArticleEuropean journal of neurology2021

Protein tyrosine phosphatase receptor type Q in cerebrospinal fluid reflects ependymal cell dysfunction and is a potential biomarker for adult chronic hydrocephalus.

M Nakajima, T Rauramaa, P M Mäkinen, M Hiltunen, S-K Herukka, M Kokki, T Musialowicz, H-K Jyrkkänen, N Danner, A Junkkari and 13 more

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04856839 (Phenotypes, Biomarkers and Pathophysiology in Syringomyelia), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04856839 unknown statusnot on this map

Phenotypes, Biomarkers and Pathophysiology in Syringomyelia

TypeobservationalSponsorXuanwu Hospital, BeijingRan2021 to 2025Enrolled200ConditionsSyringomyelia/HydromyeliaArmshigh throughput sequencing and electromyography
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Cerebrospinal Fluid Biomarkers in iNPH: A Narrative Review.Diagnostics (Basel, Switzerland) · 2022
    Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 3 institutions in 2 countries.

M NakajimaDepartment of Neurosurgery, Juntendo University Faculty of Medicine, Tokyo, Japan.ORCID 0000-0002-8496-2973
T RauramaaInstitute of Clinical Medicine－Pathology, University of Eastern, Finland.ORCID 0000-0002-2250-327X
P M MäkinenInstitute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
M HiltunenInstitute of Biomedicine, University of Eastern Finland, Kuopio, Finland.ORCID 0000-0003-3566-4096
S-K HerukkaInstitute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland.
M KokkiDepartment of Anaesthesiology and Intensive Care, Kuopio University Hospital, Kuopio, Finland.ORCID 0000-0003-1501-7537
T MusialowiczDepartment of Anaesthesiology and Intensive Care, Kuopio University Hospital, Kuopio, Finland.ORCID 0000-0002-1863-7152
H-K JyrkkänenInstitute of Clinical Medicine－Neurosurgery, University of Eastern, Finland.
N DannerInstitute of Clinical Medicine－Neurosurgery, University of Eastern, Finland.ORCID 0000-0002-7094-4432
A JunkkariInstitute of Clinical Medicine－Neurosurgery, University of Eastern, Finland.ORCID 0000-0001-8715-1749
A M KoivistoInstitute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland.
J E JääskeläinenInstitute of Clinical Medicine－Neurosurgery, University of Eastern, Finland.ORCID 0000-0003-4506-5345
M MiyajimaDepartment of Neurosurgery, Juntendo University Faculty of Medicine, Tokyo, Japan.
I OginoDepartment of Neurosurgery, Juntendo University Faculty of Medicine, Tokyo, Japan.
A FurutaDepartment of Psychiatry and Behavioural Science, Juntendo University Faculty of Medicine, Tokyo, Japan.
C AkibaDepartment of Neurosurgery, Juntendo University Faculty of Medicine, Tokyo, Japan.ORCID 0000-0001-5475-5271
K KawamuraDepartment of Neurosurgery, Juntendo University Faculty of Medicine, Tokyo, Japan.ORCID 0000-0001-9956-5797
C KamoharaDepartment of Neurosurgery, Juntendo University Faculty of Medicine, Tokyo, Japan.ORCID 0000-0002-8947-8291
H SuganoDepartment of Neurosurgery, Juntendo University Faculty of Medicine, Tokyo, Japan.ORCID 0000-0002-7836-6585
Y TangeDepartment of Neurosurgery, Juntendo University Faculty of Medicine, Tokyo, Japan.
K KaragiozovDepartment of Neurosurgery, Juntendo University Faculty of Medicine, Tokyo, Japan.ORCID 0000-0001-6105-0480
V LeinonenInstitute of Clinical Medicine－Neurosurgery, University of Eastern, Finland.ORCID 0000-0002-4282-4687
H AraiDepartment of Neurosurgery, Juntendo University Faculty of Medicine, Tokyo, Japan.
Juntendo University · JPUniversity of Eastern Finland · FIKuopio University Hospital · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeProtein tyrosine phosphatase receptor type Q (PTPRQ) was extracted from the cerebrospinal fluid (CSF) of patients with probable idiopathic normal-pressure hydrocephalus (iNPH) by proteome analysis. We aimed to assess the feasibility of using CSF PTPRQ concentrations for the additional diagnostic criterion of iNPH in Japanese and Finnish populations.

methodsWe compared PTPRQ concentrations among patients with probable iNPH and neurologically healthy individuals (normal control [NC] group), patients with normal-pressure hydrocephalus (NPH) of acquired and congenital/developmental aetiologies, patients with Alzheimer's disease and patients with Parkinson's disease in a Japanese analysis cohort. A corresponding iNPH group and NC group in a Finnish cohort was used for validation. Patients in the Finnish cohort who underwent biopsy were classified into two groups based on amyloid and/or tau deposition. We measured PTPRQ expression levels in autopsied brain specimens of iNPH patients and the NC group.

resultsCerebrospinal fluid PTPRQ concentrations in the patients with NPH of idiopathic, acquired and congenital/developmental aetiologies were significantly higher than those in the NC group and those with Parkinson's disease, but iNPH showed no significant differences when compared with those in the Alzheimer's disease group. For the patients with iNPH, the area under the receiver-operating characteristic curve was 0.860 in the Japanese iNPH and 0.849 in the Finnish iNPH cohorts. Immunostaining and in situ hybridization revealed PTPRQ expression in the ependymal cells and choroid plexus. It is highly possible that the elevated PTPRQ levels in the CSF are related to ependymal dysfunction from ventricular expansion.

conclusionsCerebrospinal fluid PTPRQ levels indicated the validity of this assay for auxiliary diagnosis of adult chronic hydrocephalus.

Indexed as

Alzheimer DiseaseHydrocephalus, Normal PressureAdultAmyloid beta-PeptidesBiomarkersHumansProtein Tyrosine PhosphatasesReceptor-Like Protein Tyrosine Phosphatases, Class 3Amyloid beta-PeptidesBiomarkersProtein Tyrosine PhosphatasesPTPRQ protein, humanReceptor-Like Protein Tyrosine Phosphatases, Class 3biomarkercerebrospinal fluididiopathic normal-pressure hydrocephalusprotein tyrosine phosphatase receptor type QRNA in situ hybridization

Identifiers

PMID33035386
PMCPMC7821334
OpenAlexW3092405905

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.