Evidence map›Paper›PMID 33035373›Full record

SynthesisReviews in medical virology2021

Comparison of influenza type A and B with COVID-19: A global systematic review and meta-analysis on clinical, laboratory and radiographic findings.

Ali Pormohammad, Saied Ghorbani, Alireza Khatami, Mohammad Hossein Razizadeh, Ehsan Alborzi, Mohammad Zarei, Juan-Pablo Idrovo, Raymond J Turner

Open access · bronzeAbstract readComparative StudyMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Reviews in medical virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 4 pooled it
2.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 4 syntheses or guidelines pooled it, 127 citations in OpenAlex.

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12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Ali PormohammadDepartment of Biological Sciences, University of Calgary, Calgary, Alberta, Canada.ORCID https://orcid.org/0000-0002-7542-4794
Saied GhorbaniDepartment of Virology, Faculty of Medicine, Iran University of Medical Science, Tehran, Iran.ORCID https://orcid.org/0000-0001-9284-6983
Alireza KhatamiDepartment of Virology, Faculty of Medicine, Iran University of Medical Science, Tehran, Iran.
Mohammad Hossein RazizadehDepartment of Virology, Faculty of Medicine, Iran University of Medical Science, Tehran, Iran.
Ehsan AlborziDepartment of Virology, Faculty of Medicine, Iran University of Medical Science, Tehran, Iran.
Mohammad ZareiDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-2239-2055
Juan-Pablo IdrovoDivision of GI, Trauma and Endocrine Surgery, Department of Surgery, University of Colorado, Denver, Colorado, USA.
Raymond J TurnerDepartment of Biological Sciences, University of Calgary, Calgary, Alberta, Canada.
Iran University of Medical Sciences · IRUniversity of Calgary · CAChildren's Hospital of Philadelphia · USUniversity of Colorado Denver · US

Funding

Hepatic Response in Advance Age after Burn InjuryK08GM134185 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI IDROVO, JUAN PABLO · 2019 to 2023
$945k
NIGMS NIH HHS K08 GM134185
6 · The paper itself

Abstract

We compared clinical symptoms, laboratory findings, radiographic signs and outcomes of COVID-19 and influenza to identify unique features. Depending on the heterogeneity test, we used either random or fixed-effect models to analyse the appropriateness of the pooled results. Overall, 540 articles included in this study; 75,164 cases of COVID-19 (157 studies), 113,818 influenza type A (251 studies) and 9266 influenza type B patients (47 studies) were included. Runny nose, dyspnoea, sore throat and rhinorrhoea were less frequent symptoms in COVID-19 cases (14%, 15%, 11.5% and 9.5%, respectively) in comparison to influenza type A (70%, 45.5%, 49% and 44.5%, respectively) and type B (74%, 33%, 38% and 49%, respectively). Most of the patients with COVID-19 had abnormal chest radiology (84%, p < 0.001) in comparison to influenza type A (57%, p < 0.001) and B (33%, p < 0.001). The incubation period in COVID-19 (6.4 days estimated) was longer than influenza type A (3.4 days). Likewise, the duration of hospitalization in COVID-19 patients (14 days) was longer than influenza type A (6.5 days) and influenza type B (6.7 days). Case fatality rate of hospitalized patients in COVID-19 (6.5%, p < 0.001), influenza type A (6%, p < 0.001) and influenza type B was 3%(p < 0.001). The results showed that COVID-19 and influenza had many differences in clinical manifestations and radiographic findings. Due to the lack of effective medication or vaccine for COVID-19, timely detection of this viral infection and distinguishing from influenza are very important.

Indexed as

CoughCOVID-19DyspneaElectronic Health RecordsFeverHumansInfectious Disease Incubation PeriodInfluenza A virusInfluenza B virusInfluenza, HumanPharyngitisRespiratory Tract InfectionsRhinorrheaSARS-CoV-2Severity of Illness IndexSurvival AnalysiscoronavirusCOVID-19influenzameta-analysisSARS-Cov-2

Identifiers

PMID33035373
PMCPMC7646051
OpenAlexW3092265774

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.