Evidence map›Paper›PMID 33035257›Full record

Observational studyPloS one2020

A factor score reflecting cognitive functioning in patients from the Swiss Atrial Fibrillation Cohort Study (Swiss-AF).

Anne Springer, Andreas U Monsch, Gilles Dutilh, Michael Coslovsky, Rogier A Kievit, Leo H Bonati, David Conen, Stefanie Aeschbacher, Juerg H Beer, Matthias Schwenkglenks and 8 more

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Observational
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 8 institutions in 3 countries.

Anne SpringerCardiology Division, Department of Medicine, University Hospital Basel, Basel, Switzerland.ORCID 0000-0002-4829-1041
Andreas U MonschMemory Clinic, University Department of Geriatric Medicine FELIX PLATTER, Basel, Switzerland.
Gilles DutilhDepartment of Clinical Research, Clinical Trial Unit, University of Basel Hospital, Basel, Switzerland.
Michael CoslovskyCardiology Division, Department of Medicine, University Hospital Basel, Basel, Switzerland.
Rogier A KievitDonders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands.ORCID 0000-0003-0700-4568
Leo H BonatiDepartment of Neurology and Stroke Center, University Hospital Basel, University of Basel, Basel, Switzerland.
David ConenCardiovascular Research Institute Basel (CRIB), Basel, Switzerland.
Stefanie AeschbacherCardiology Division, Department of Medicine, University Hospital Basel, Basel, Switzerland.
Juerg H BeerDepartment of Medicine, Cantonal Hospital of Baden and Molecular Cardiology, University Hospital of Zurich, Zurich, Switzerland.
Matthias SchwenkglenksEpidemiology, Biostatistics, and Prevention Institute, University of Zurich, Zurich, Switzerland.ORCID 0000-0001-7217-1173
Urs FischerDepartment of Neurology, Inselspital, Bern University Hospital, University of Bern, Switzerland.
Christine S Meyer-ZuernCardiology Division, Department of Medicine, University Hospital Basel, Basel, Switzerland.
Giulio ConteCardiocentro Ticino, Lugano, Switzerland.
Elisavet MoutzouriInstitute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.
Giorgio MoschovitisPopulation Health Research Institute, McMaster University, Hamilton, Canada.
Michael KühneCardiology Division, Department of Medicine, University Hospital Basel, Basel, Switzerland.
Stefan OsswaldCardiology Division, Department of Medicine, University Hospital Basel, Basel, Switzerland.ORCID 0000-0002-9240-6731
Swiss-AF Study Investigators
University Hospital of Basel · CHUniversity of Basel · CHPopulation Health Research Institute · CAUniversity of Bern · CHEpatocentro Ticino · CHRadboud University Nijmegen · NLUniversity Hospital of Zurich · CHUniversity of Zurich · CH

Funding

Medical Research Council MC_UP_1401/1Medical Research Council MC_UU_00005/9
6 · The paper itself

Abstract

backgroundAtrial fibrillation (AF), the most common sustained cardiac arrhythmia, is considered as risk factor for the development of mild cognitive impairment (MCI) and dementia. However, dynamics of cognitive functions are subtle, and neurocognitive assessments largely differ in detecting these changes. We aimed to develop and evaluate a score which represents the common aspects of the cognitive functions measured by validated tests (i.e., "general cognitive construct"), while reducing overlap between tests and be more sensitive to identify changes in overall cognitive functioning.

methodsWe developed the CoCo (cognitive construct) score to reflect the cognitive performance obtained by all items of four neurocognitive assessments (Montreal Cognitive Assessment (MoCA); Trail Making Test; Semantic Fluency, animals; Digital Symbol Substitution Test). The sample comprised 2,415 AF patients from the Swiss Atrial Fibrillation Cohort Study (Swiss-AF), 87% aged at least 65 years. Psychometric statistics were calculated for two cognitive measures based on (i) the full set of items from the neurocognitive test battery administered in the Swiss-AF study (i.e., CoCo item set) and (ii) the items from the widely used MoCA test. For the CoCo item set, a factor score was derived based on a principal component analysis, and its measurement properties were analyzed.

resultsBoth the MoCA item set and the full neurocognitive test battery revealed good psychometric properties, especially the full battery. A one-factor model with good model fit and performance across time and groups was identified and used to generate the CoCo score, reflecting for each patient the common cognitive skill performance measured across the full neurocognitive test battery. The CoCo score showed larger effect sizes compared to the MoCA score in relation to relevant clinical variables.

conclusionThe derived factor score allows summarizing AF patients' cognitive performance as a single score. Using this score in the Swiss-AF project increases measurement sensitivity and decreases the number of statistical tests needed, which will be helpful in future studies addressing how AF affects the risk of developing cognitive impairment.

Indexed as

AgedAged, 80 and overAtrial FibrillationCognitionCognitive DysfunctionFemaleHumansMaleNeuropsychological TestsPsychometrics

Identifiers

PMID33035257
PMCPMC7546506
OpenAlexW3091976495

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.