Evidence map›Paper›PMID 33034673›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2021

Improving staging of rectal cancer in the pelvis: the role of PET/MRI.

Onofrio A Catalano, Susanna I Lee, Chiara Parente, Christy Cauley, Felipe S Furtado, Robin Striar, Andrea Soricelli, Marco Salvatore, Yan Li, Lale Umutlu and 13 more

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06265272 (Technical Development and Clinical Validation of a Comprehensive One-stop Shop Assessment of the Cirrhotic Liver With [68Ga]Ga-PSMA-11 PET/MRI), which is not on this map. Cited by 31 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 3 pooled it
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06265272 recruitingnot on this mapstarted 2023, after this paper: background citation

Technical Development and Clinical Validation of a Comprehensive One-stop Shop Assessment of the Cirrhotic Liver With [68Ga]Ga-PSMA-11 PET/MRI

TypeobservationalSponsorMassachusetts General HospitalRan2023 to 2026Enrolled45ConditionsLiver Cirrhosis, Hepatic Cell Carcinoma, Portal HypertensionArmsInjection of a gadolinium contrast agen, Radiotracer Injection, Imaging
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 58 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Diagnostic performance of [European journal of nuclear medicine and molecular imaging · 2022
    Pooled it
  4. Trial
  5. Diagnostic performance of [Abdominal radiology (New York) · 2026
    Article
  6. Review
  7. Diagnostic Performance of [World journal of nuclear medicine · 2025
    Review
  8. Article
  9. Review
  10. Radiotherapy volume delineation based on MRI andAbdominal radiology (New York) · 2025
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. PET/MRI in colorectal and anal cancers: an update.Abdominal radiology (New York) · 2023
    Review
  16. Nuclear Medicine and Cancer Theragnostics: Basic Concepts.Diagnostics (Basel, Switzerland) · 2023
    Review
  17. Article
  18. Imaging in translational cancer research.Cancer biology & medicine · 2022
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 7 institutions in 5 countries.

Onofrio A CatalanoDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, White Building Rm 250, 55 Fruit St, Boston, MA, 02114, USA. ocatalano@mgh.harvard.edu.ORCID https://orcid.org/0000-0001-7733-4138
Susanna I LeeDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, White Building Rm 250, 55 Fruit St, Boston, MA, 02114, USA.
Chiara ParenteSDN IRCCS, Naples, Italy.
Christy CauleyDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Felipe S FurtadoDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, White Building Rm 250, 55 Fruit St, Boston, MA, 02114, USA.
Robin StriarDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, White Building Rm 250, 55 Fruit St, Boston, MA, 02114, USA.
Andrea SoricelliDepartment of Radiology, University of Naples "Parthenope", Naples, Italy.
Marco SalvatoreSDN IRCCS, Naples, Italy.
Yan LiDepartment of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany.
Lale UmutluDepartment of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany.
Lina Garcia CañamaqueHospital Universitario Madrid Sanchinarro, Madrid, Spain.
David GrosharDepartment of Nuclear Medicine, Assuta Medical Centers, Tel Aviv, Israel.
Umar MahmoodDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, White Building Rm 250, 55 Fruit St, Boston, MA, 02114, USA.
Lawrence S BlaszkowskyCancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
David P RyanCancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Jeffrey W ClarkCancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Jennifer WoDepartment of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Theodore S HongDepartment of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Hiroko KunitakeDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Liliana BordeianouDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
David BergerDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Rocco RicciardiDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Bruce RosenDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, White Building Rm 250, 55 Fruit St, Boston, MA, 02114, USA.
Harvard University · USEssen University Hospital · DEHospital Universitario HM Sanchinarro · ESParthenope University of Naples · ITSDN Istituto di Ricerca Diagnostica e Nucleare · ITTel Aviv University · ILUniversità degli Studi Suor Orsola Benincasa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe role of positron emission tomography/magnetic resonance (PET/MR) in evaluating the local extent of rectal cancer remains uncertain. This study aimed to investigate the possible role of PET/MR versus magnetic resonance (MR) in clinically staging rectal cancer.

methodsThis retrospective two-center cohort study of 62 patients with untreated rectal cancer investigated the possible role of baseline staging PET/MR versus stand-alone MR in determination of clinical stage. Two readers reviewed T and N stage, mesorectal fascia involvement, tumor length, distance from the anal verge, sphincter involvement, and extramural vascular invasion (EMVI). Sigmoidoscopy, digital rectal examination, and follow-up imaging, along with surgery when available, served as the reference standard.

resultsPET/MR outperformed MR in evaluating tumor size (42.5 ± 21.03 mm per the reference standard, 54 ± 20.45 mm by stand-alone MR, and 44 ± 20 mm by PET/MR, P = 0.004), and in identifying N status (correct by MR in 36/62 patients [58%] and by PET/MR in 49/62 cases [79%]; P = 0.02) and external sphincter infiltration (correct by MR in 6/10 and by PET/MR in 9/10; P = 0.003). No statistically significant differences were observed in relation to any other features.

conclusionPET/MR provides a more precise assessment of the local extent of rectal cancers in evaluating cancer length, N status, and external sphincter involvement. PET/MR offers the opportunity to improve clinical decision-making, especially when evaluating low rectal tumors with possible external sphincter involvement.

Indexed as

Magnetic Resonance ImagingRectal NeoplasmsCohort StudiesHumansNeoplasm StagingPelvisPositron-Emission TomographyRetrospective StudiesMRIPETPET/MRPET/MRIRectal cancerStaging

Identifiers

PMID33034673
OpenAlexW3092072056

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Registered trials

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