Evidence map›Paper›PMID 33034629›Full record

SynthesisSleep2021

Multi-ethnic GWAS and meta-analysis of sleep quality identify MPP6 as a novel gene that functions in sleep center neurons.

Samar Khoury, Qiao-Ping Wang, Marc Parisien, Pavel Gris, Andrey V Bortsov, Sarah D Linnstaedt, Samuel A McLean, Andrew S Tungate, Tamar Sofer, Jiwon Lee and 15 more

Open access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Sleep, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Sleep regulation inFrontiers in neuroscience · 2026
    Review
  3. Article
  4. Mettl3-mCell discovery · 2025
    Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 11 institutions in 5 countries.

Samar KhouryThe Alan Edwards Centre for Research on Pain, McGill University, Montréal, QC, Canada.
Qiao-Ping WangSchool of Pharmaceutical Sciences (Shenzhen), Sun Yat-Sen University, Guangzhou, China.
Marc ParisienThe Alan Edwards Centre for Research on Pain, McGill University, Montréal, QC, Canada.
Pavel GrisThe Alan Edwards Centre for Research on Pain, McGill University, Montréal, QC, Canada.
Andrey V BortsovCenter for Translational Pain Medicine, Department of Anesthesiology, Duke University, Durham, NC.
Sarah D LinnstaedtInstitute for Trauma Recovery and Department of Anesthesiology, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Samuel A McLeanInstitute for Trauma Recovery and Department of Anesthesiology, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Andrew S TungateInstitute for Trauma Recovery and Department of Anesthesiology, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Tamar SoferDepartment of Medicine, Division of Sleep and Circadian Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Jiwon LeeDepartment of Medicine, Division of Sleep and Circadian Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Tin LouieDepartment of Biostatistics, University of Washington, Seattle, WA.
Susan RedlineDepartment of Medicine, Division of Sleep and Circadian Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Mari Anneli KaunistoDepartment of Diagnostics and Therapeutics, University of Helsinki, Helsinki, Finland.
Eija A KalsoDepartment of Diagnostics and Therapeutics, University of Helsinki, Helsinki, Finland.
Hans Markus MunterDepartment of Human Genetics, McGill University, Montréal, QC, Canada.
Andrea G NackleyCenter for Translational Pain Medicine, Department of Anesthesiology, Duke University, Durham, NC.
Gary D SladeSchool of dentistry, University of North Carolina Chapel Hill, Chapel Hill, NC.
Shad B SmithCenter for Translational Pain Medicine, Department of Anesthesiology, Duke University, Durham, NC.
Dmitri V ZaykinBiostatistics and Computational Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC.
Roger B FillingimCollege of Dentistry, University of Florida, Gainesville, FL.
Richard OhrbachDepartment of Oral Diagnostic Services, University at Buffalo, Buffalo, NY.
Joel D GreenspanDepartment of Neural and Pain Sciences, Brotman Facial Pain Clinic, School of Dentistry and Center to Advance Chronic Pain Research, University of Maryland, Baltimore, MD.
William MaixnerCenter for Translational Pain Medicine, Department of Anesthesiology, Duke University, Durham, NC.
G Gregory NeelyThe Dr. John and Anne Chong Laboratory for Functional Genomics, Charles Perkins Centre and School of Life & Environmental Sciences, The University of Sydney, Sydney, NSW, Australia.
Luda DiatchenkoThe Alan Edwards Centre for Research on Pain, McGill University, Montréal, QC, Canada.
McGill University · CADuke University · USUniversity of North Carolina at Chapel Hill · USBrigham and Women's Hospital · USUniversity of Helsinki · FINational Institutes of Health · USSun Yat-sen University · CNThe University of Sydney · AUUniversity of Florida · USUniversity of Maryland, Baltimore · USUniversity of Washington · US

Funding

Risk Factors for Onset and Persistence of TMDU01DE017018 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DIATCHENKO, LUDA, FILLINGIM, ROGER B · 2005 to 2016
$35.9M
University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI Peihua Qiu · 2007 to 2026
$22.8M
Vulvar Vestibulitis syndrome (VVS)P01NS045685 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GRACELY, RICHARD H · 2004 to 2014
$12.5M
Phenotypic and Molecular Signatures for Sleep Apnea and Related MorbiditiesR35HL135818 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI REDLINE, SUSAN S. · 2017 to 2023
$7.2M
Statistical, population genetics and genetic epidemiologyZIAES101866 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI ZAYKIN, DMITRI V · 2009 to 2021
$5.8M
Leveraging Family Data to Identify Genetic Variants for Sleep ApneaR01HL113338 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LIN, XIHONG, REDLINE, SUSAN S. · 2012 to 2016
$4.4M
FAMILIAL AGGREGATION OF OBSTRUCTIVE SLEEP APNEAR01HL046380 · NHLBI · UNIVERSITY HOSPITALS OF CLEVELAND · PI REDLINE, SUSAN S · 1990 to 2005
$3.5M
Thalassemia Clinical Research Network, CanadaU01HL065233 · NHLBI · UNIVERSITY HEALTH NETWORK · PI OLIVIERI, NANCY F · 2000 to 2009
$2.6M
GENETIC ARCHITECTURE OF PLASMA T-PA AND PAI-1R01HL065234 · NHLBI · VANDERBILT UNIVERSITY · PI MOORE, JASON H. · 2000 to 2004
$1.7M
Biomedical Researcher Development Program in TMJD and Orofacial PainK12DE022793 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIM, PEI FENG, MAIXNER, WILLIAM · 2012 to 2016
$1.3M
HISPANIC COMMUNITY HEALTH STUDY-268065233N01HC065233 · HC · COORDINATING CENTER · PI CHAMBLESS, LLOYD E · 2006 to 2006
–
NCI NIH HHS HHSN261201300004INCI NIH HHS HHSN261201300005INHGRI NIH HHS HHSN268201300003CNHLBI NIH HHS HHSN268201000021CNHLBI NIH HHS HHSN268201000031CNHLBI NIH HHS HHSN268201200008CNHLBI NIH HHS HHSN268201200008INHLBI NIH HHS HHSN268201300001CNHLBI NIH HHS HHSN268201300003INHLBI NIH HHS HHSN268201300004CNHLBI NIH HHS HHSN268201300005CNHLBI NIH HHS HHSN268201800010INHLBI NIH HHS HHSN268201800011CNHLBI NIH HHS HHSN268201800011INHLBI NIH HHS HHSN268201800012CNHLBI NIH HHS HHSN268201800012INHLBI NIH HHS HHSN268201800015INHLBI NIH HHS N01 HC065233NHLBI NIH HHS N01 HC065234NHLBI NIH HHS N01 HC065235NHLBI NIH HHS N01 HC065236NHLBI NIH HHS N01 HC065237NHLBI NIH HHS R01 HL046380NHLBI NIH HHS R01 HL113338NHLBI NIH HHS R35 HL135818NIA NIH HHS P30 AG028740NIDCR NIH HHS K12 DE022793NIDCR NIH HHS U01 DE017018NIMHD NIH HHS HHSN268201800013ININDS NIH HHS P01 NS045685
6 · The paper itself

Abstract

Poor sleep quality can have harmful health consequences. Although many aspects of sleep are heritable, the understandings of genetic factors involved in its physiology remain limited. Here, we performed a genome-wide association study (GWAS) using the Pittsburgh Sleep Quality Index (PSQI) in a multi-ethnic discovery cohort (n = 2868) and found two novel genome-wide loci on chromosomes 2 and 7 associated with global sleep quality. A meta-analysis in 12 independent cohorts (100 000 individuals) replicated the association on chromosome 7 between NPY and MPP6. While NPY is an important sleep gene, we tested for an independent functional role of MPP6. Expression data showed an association of this locus with both NPY and MPP6 mRNA levels in brain tissues. Moreover, knockdown of an orthologue of MPP6 in Drosophila melanogaster sleep center neurons resulted in decreased sleep duration. With convergent evidence, we describe a new locus impacting human variability in sleep quality through known NPY and novel MPP6 sleep genes.

Indexed as

Drosophila melanogasterGenome-Wide Association StudyAnimalsEthnicityGenetic Predisposition to DiseaseHumansMembrane ProteinsNeuronsPolymorphism, Single NucleotideSleepMembrane ProteinsMPP6 protein, humangenome-wide association studyMPP6sleep centerssleep quality

Identifiers

PMID33034629
PMCPMC7953222
OpenAlexW3092051401

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.