ArticleThe EMBO journal2020
Frozen? Let it go to reset circadian rhythms.
Article in The EMBO journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 3 citations in OpenAlex.
- Cryopreservation of siRNA-Treated Cells Is Feasible.Nucleic acid therapeutics · 2025Article
- Frozen? Let it go to reset circadian rhythms.The EMBO journal · 2020Article
Corrections and comments
- Comment on
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The molecular events in response to severe hyperthermia are not fully understood, and research has focused mainly on the effects of cooling at temperatures between 28°C and 35°C. In a new study, Fischl et al have analysed human cardiomyocytes at lower temperatures (8°C, 18°C and 28°C) and identified a novel mechanism by which hypothermia synchronises the circadian clock: cooling induces nuclear accumulation of transcripts that encode negative regulators of the circadian clock, which are released into the cytoplasm upon rewarming allowing synthesis of specific clock proteins.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.