ArticleBiological trace element research2021
Slightly Elevated Serum Ionic Fluoride Levels Inhibit Insulin Secretion and Increase Glucose Levels in a General Japanese Population: a Cross-sectional Study.
Article in Biological trace element research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Fluoride Exposure from Drinking Water Increases the Risk of Stroke: An Ecological Study in Changwu Town, China.Toxics · 2024Article
- Effect of training on bone quality in rats with insulin resistance induce by fluoride consumption.Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina) · 2024Article
- Longitudinal associations between early-life fluoride exposures and cardiometabolic outcomes in school-aged children.Environment international · 2024Article
- Necessity to Pay Attention to the Effects of Low Fluoride on Human Health: an Overview of Skeletal and Non-skeletal Damages in Epidemiologic Investigations and Laboratory Studies.Biological trace element research · 2023Review
- Role of renal function in the association of drinking water fluoride and plasma fluoride among adolescents in the United States: NHANES, 2013-2016.Environmental research · 2022Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A cross-sectional study was performed to investigate the relationships between serum fluoride levels, glucose levels, and insulin secretion in a general population. A total of 330 healthy subjects (167 men; 163 women) aged between 40 and 69 years were examined. Lifestyle information was obtained using questionnaires. Blood samples were collected in the early morning, and biochemical parameters and glucose indices were measured. Serum ionic fluoride (SIF) levels were assessed using a highly sensitive method. Relationships between glucose indices and SIF levels were investigated using a multiple linear regression analysis. SIF levels positively correlated with fasting plasma glucose (FPG) and glycohemoglobin (HbA1c) levels in both sexes. In women, SIF levels negatively correlated with homeostasis model assessment insulin secretion (HOMA-β) levels. In men, the proportion of regular drinkers negatively correlated with HOMA-β, but not SIF levels. Although SIF levels < 1 μmol/L were associated with reduced insulin secretion and increased FPG levels, the risk of diabetes was not elevated. These results suggest that increased SIF levels caused by a large fluoride intake and compromised renal function combined with poor lifestyle choices elevate the risk of diabetes. Further studies are warranted to elucidate the effects of fluoride on glucose metabolism.
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