ArticleGeroScience2021
Association between genetically predicted telomere length and facial skin aging in the UK Biobank: a Mendelian randomization study.
Article in GeroScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Integrative In Silico and In Vitro Evaluation of Vialox and Leuphasyl Pentapeptides for Antiaging Applications.Chemistry & biodiversity · 2026Article
- Distinct roles of chronotype, daytime napping, and sleep duration in biological and functional aging: a univariable and multivariable Mendelian randomization study.Clinical epigenetics · 2026Article
- Facial skin aging is a potential osteoporosis-associated marker: evidence from both observational and genetic studies.Journal of bone and mineral metabolism · 2026Article
- Genetic profiling and precision skin care: a review.Frontiers in genetics · 2025Review
- Facial aging, cognitive impairment, and dementia risk.Alzheimer's research & therapy · 2024Article
- The association of psychological and trauma-related factors with biological and facial aging acceleration: evidence from the UK Biobank.BMC medicine · 2024Article
- Impact of childhood maltreatment on aging: a comprehensive Mendelian randomization analysis of multiple age-related biomarkers.Clinical epigenetics · 2024Article
- Genetic insights into the gut microbiota and risk of facial skin aging: A Mendelian randomization study.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024Article
- Obesity, Glycemic Traits, Lifestyle Factors, and Risk of Facial Aging: A Mendelian Randomization Study in 423,999 Participants.Aesthetic plastic surgery · 2024Article
- Genetically Proxied Autoimmune Diseases and the Risk of Facial Aging.Clinical, cosmetic and investigational dermatology · 2024Article
- Geroscience and pathology: a new frontier in understanding age-related diseases.Pathology oncology research : POR · 2024Review
- Associations between Sjogren syndrome and psychiatric disorders in European populations: a 2-sample bidirectional Mendelian randomization study.Frontiers in psychiatry · 2024Article
- Association between adiposity and facial aging: results from a Mendelian randomization study.European journal of medical research · 2023Article
- Risk relationship between leukocyte telomere length and constipation: a Mendelian randomization study.Frontiers in medicine · 2023Article
- Telomere length is causally connected to brain MRI image derived phenotypes: A mendelian randomization study.PloS one · 2022Article
- Accelerated ageing is associated with increased COVID-19 severity and differences across ethnic groups may exist.Frontiers in public health · 2022Article
- Mendelian Randomization Study of Causal Relationship between Omega-3 Fatty Acids and Risk of Lung Cancer.BioMed research international · 2022Article
- Genetically Predicted Telomere Length and Its Relationship With Alzheimer's Disease.Frontiers in genetics · 2021Article
- Cytomegalovirus Infection and Its Relationship with Leukocyte Telomere Length: A Cross-Sectional Study.Mediators of inflammation · 2021Article
- Telomere Length as a Marker of Biological Age: State-of-the-Art, Open Issues, and Future Perspectives.Frontiers in genetics · 2020Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Are shorter telomeres causal risk factors for facial aging on a large population level? To examine if longer, genetically predicted telomeres were causally associated with less facial aging using Mendelian randomization analysis. Two-sample Mendelian randomization methods were applied to the summary statistics of a genome-wide association study (GWAS) for self-reported facial aging from 417, 772 participants of the UK Biobank data. Twenty single-nucleotide polymorphisms (SNPs) that were of genome-wide significance were selected as instrumental variables for leukocyte telomere length. The main analyses were performed primarily using the random-effects inverse-variance weighted method and were complemented with the MR-Egger regression, weighted median, and weighted mode approaches. The intercept of MR-Egger regression was used to assess horizontal pleiotropy. Longer genetically predicted telomeres were associated with a lower likelihood of facial aging (β = - 0.02, 95% confidence interval: - 0.04, - 0.002). Comparable results were obtained using MR-Egger regression, weighted median, and weighted mode approaches. The intercept of MR-Egger regression was close to zero (0.002) that was not suggestive of horizontal pleiotropy. Our findings provided evidence to support a potential causal relationship between longer genetically predicted telomeres and less facial aging.
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