Evidence map›Paper›PMID 33033759›Full record

ArticleHeliyon2020

Iron deficiency negatively regulates protein methylation via the downregulation of protein arginine methyltransferase.

Hirofumi Inoue, Nobuaki Hanawa, Shin-Ichi Katsumata, Yumi Aizawa, Rie Katsumata-Tsuboi, Miori Tanaka, Nobuyuki Takahashi, Mariko Uehara

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Structure, Activity, and Function of PRMT1.Life (Basel, Switzerland) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hirofumi InoueDepartment of Nutritional Science and Food Safety, Faculty of Applied Bioscience, Tokyo University of Agriculture, Japan.
Nobuaki HanawaDepartment of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture, Japan.
Shin-Ichi KatsumataDepartment of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture, Japan.
Yumi AizawaDepartment of Agricultural Chemistry, Faculty of Applied Biosciences, Tokyo University of Agriculture, Tokyo, Japan.
Rie Katsumata-TsuboiDepartment of Nutritional Science and Food Safety, Faculty of Applied Bioscience, Tokyo University of Agriculture, Japan.
Miori TanakaDepartment of Nutritional Science and Food Safety, Faculty of Applied Bioscience, Tokyo University of Agriculture, Japan.
Nobuyuki TakahashiDepartment of Nutritional Science and Food Safety, Faculty of Applied Bioscience, Tokyo University of Agriculture, Japan.
Mariko UeharaDepartment of Nutritional Science and Food Safety, Faculty of Applied Bioscience, Tokyo University of Agriculture, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Iron is an essential trace metal for all biological processes and plays a role in almost every aspect of body growth. Previously, we found that iron-depletion downregulated the expression of proteins, arginine methyltransferase-1 and 3 (PRMT1 and PRMT3), by an iron-specific chelator, deferoxamine (DFO), in rat liver FAO cell line using DNA microarray analysis (unpublished data). However, regulatory mechanisms underlying the association between iron deficiency and PRMT expression are unclear

Indexed as

BiochemistryCell biologyCell cultureDeferasiroxDeferoxamineFAO cellsGene expressionGeneticsIron-deficiencyMicroarrayMolecular biologyPRMT1PRMT3Protein methylationRats

Identifiers

PMID33033759
PMCPMC7533365

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.